Evidence map›Paper›PMID 25461774›Full record

ReviewMethods (San Diego, Calif.)2015

Assaying the epigenome in limited numbers of cells.

William J Greenleaf

Abstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

William J GreenleafDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, United States. Electronic address: wjg@stanford.edu.

Funding

VACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7M
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2M
Mapping chromatin secondary structure by sequencing correlated DNA strand breaksR21HG007726 · NHGRI · STANFORD UNIVERSITY · PI GREENLEAF, WILLIAM JAMES · 2014 to 2015
$441k
NHGRI NIH HHS P50 HG007735NHGRI NIH HHS P50HG007735NHGRI NIH HHS R21 HG007726NIAID NIH HHS U19 AI057266NIAID NIH HHS U19AI057266
6 · The paper itself

Abstract

Spectacular advances in the throughput of DNA sequencing have allowed genome-wide analysis of epigenetic features such as methylation, nucleosome position and post-translational modification, chromatin accessibility and connectivity, and transcription factor binding. However, for rare or precious biological samples, input requirements of many of these methods limit their application. In this review we discuss recent advances for low-input genome-wide analysis of chromatin immunoprecipitation, methylation, DNA accessibility, and chromatin conformation.

Indexed as

Chromatin ImmunoprecipitationDNA MethylationEpigenesis, GeneticEpigenomicsGenome, HumanHumansSingle-Cell AnalysisChromatinEpigenomeHigh-throughput sequencingMethylationSingle cell

Identifiers

PMID25461774
PMCPMC4412609

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.