ArticleJournal of pain and symptom management2015
A longitudinal study of depression, fatigue, and sleep disturbances as a symptom cluster in women with breast cancer.
Article in Journal of pain and symptom management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- The impact of breast cancer treatment on sleep disturbance: a systematic review.Breast cancer research and treatment · 2025Pooled it
- Symptom Clusters in Head and Neck Cancer: A Systematic Review and Conceptual Model.Seminars in oncology nursing · 2021Pooled it
- Identification of Symptom Profiles in Prostate Cancer Survivors.Oncology nursing forum · 2025Trial
- Cognitive Behavioral Therapy for Insomnia Reduces Depression in Cancer Survivors.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Trial
- Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters.Journal of pain and symptom management · 2017Trial
- Relationship between fatigue, sleep quality and inflammatory cytokines during external beam radiation therapy for prostate cancer: A prospective study.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2016Trial
- "Walk for Life": A Feasibility Randomised Controlled Trial of Guolin Qigong for Fatigue, Sleep Disturbance and Depression Symptom Cluster in Cancer Survivors.Integrative cancer therapiesTrial
- Sleep Quality in Adults with Cancer: Associations with Symptom Burden and Psychological Resilience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Relationship between incident cardiovascular disease and quality of life after a breast cancer diagnosis.Journal of cancer survivorship : research and practice · 2026Article
- Challenges in postoperative self-management for patients with bladder cancer and urinary stoma: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Racial Disparities in Psychoneurological Symptoms and Health-Promoting Behaviors Among Breast Cancer Survivors: A Two-Year Longitudinal Study.Oncology nursing forum · 2026Article
- Transcutaneous vagus nerve stimulation in breast cancer: a neuroimmune model to improve quality of life.Frontiers in oncology · 2026Article
- Clinical significance and pathogenic mechanisms of fatigue in metabolic dysfunction-associated steatotic liver disease.World journal of hepatology · 2025Review
- Patients' experiences of cognitive behavioural therapy integrated with activity pacing: a qualitative study.BMC cancer · 2025Article
- Quality of Life and Age-Related Predictor Symptoms in Breast Cancer Survivors Undergoing Hormone Therapy: A Study from the Northern Region of Morocco.European journal of breast health · 2025Article
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- Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients.Journal of sport and health science · 2024Article
- Diurnal and Daily Symptom Variation in Patients with End Stage Kidney Disease: An Ecological Momentary Assessment Study.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
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26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
contextDepression, fatigue, and sleep disturbances have been identified as a symptom cluster among breast cancer patients. However, few longitudinal studies have examined the temporal relations between these symptoms surrounding diagnosis and treatment.
objectivesThe present study investigated the co-occurrence of and interrelations between nonsomatic depressive symptoms, fatigue, and sleep disturbances in breast cancer patients at three time points: before, after, and six to eight months following adjuvant chemotherapy treatment.
methodsSeparate samples of premenopausal (n = 67) and postmenopausal (n = 67) breast cancer patients completed self-report measures of depression, fatigue, and sleep disturbances at all three time points. Path analysis was used to explore within- and cross-symptom paths across time.
resultsDepression, fatigue, and sleep disturbances were correlated within each time point. Continuity paths, whereby prior levels of symptom severity tended to predict subsequent severity of the same symptom at the subsequent time point, were significant in both samples, except for depression in the premenopausal sample. Instead, significant cross-symptom paths emerged whereby baseline fatigue predicted postchemotherapy depression, and postchemotherapy fatigue predicted depression at follow-up in the premenopausal patients. No significant cross-symptom paths emerged for the postmenopausal sample.
conclusionFindings supported the notion that depression, fatigue, and sleep disturbances manifest as a symptom cluster. Fatigue may precede nonsomatic symptoms of depression among premenopausal breast cancer patients and represents a potential intervention target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.