Evidence map›Paper›PMID 25461572›Full record

ReviewCurrent opinion in microbiology2015

The impact of genomics on population genetics of parasitic diseases.

Daniel N Hupalo, Martina Bradic, Jane M Carlton

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Genomic Analyses ofPathogens (Basel, Switzerland) · 2021
    Article
  3. Community Parameters and Genome-Wide RAD-Seq Loci ofPathogens (Basel, Switzerland) · 2021
    Article
  4. The compact genome ofMicrobial genomics · 2020
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Whole-genome sequencing in outbreak analysis.Clinical microbiology reviews · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel N HupaloCenter for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, United States.
Martina BradicCenter for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, United States.
Jane M CarltonCenter for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, United States. Electronic address: jane.carlton@nyu.edu.

Funding

Using Next-Generation Genomics to Study Antimalarial Drug Resistance in IndiaU19AI089676 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OMPAD, DANIELLE C · 2010 to 2023
$22.6M
Trichomonas vaginalis repeat infections among HIV negative womenR01AI097080 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KISSINGER, PATRICIA J · 2012 to 2016
$3.7M
NIAID NIH HHS 5U19AI089676-04NIAID NIH HHS R01 AI097080NIAID NIH HHS R01AI097080NIAID NIH HHS U19 AI089676NIAID NIH HHS U19AI089676
6 · The paper itself

Abstract

Parasites, defined as eukaryotic microbes and parasitic worms that cause global diseases of human and veterinary importance, span many lineages in the eukaryotic Tree of Life. Historically challenging to study due to their complicated life-cycles and association with impoverished settings, their inherent complexities are now being elucidated by genome sequencing. Over the course of the last decade, projects in large sequencing centers, and increasingly frequently in individual research labs, have sequenced dozens of parasite reference genomes and field isolates from patient populations. This 'tsunami' of genomic data is answering questions about parasite genetic diversity, signatures of evolution orchestrated through anti-parasitic drug and host immune pressure, and the characteristics of populations. This brief review focuses on the state of the art of parasitic protist genomics, how the peculiar genomes of parasites are driving creative methods for their sequencing, and the impact that next-generation sequencing is having on our understanding of parasite population genomics and control of the diseases they cause.

Indexed as

Genetic VariationAnimalsEvolution, MolecularGenetics, PopulationGenomicsHumansParasitesParasitic Diseases

Identifiers

PMID25461572
PMCPMC4323873

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.