Evidence map›Paper›PMID 25461455›Full record

ReviewCurrent opinion in genetics & development2014

In vivo imaging of transplanted stem cells in the central nervous system.

Ben A Duffy, Andrew J Weitz, Jin Hyung Lee

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ben A DuffyDepartment of Neurology & Neurological Sciences, Stanford University, CA 94305, USA.
Andrew J WeitzDepartment of Bioengineering, Stanford University, CA 94305, USA.
Jin Hyung LeeDepartment of Neurology & Neurological Sciences, Stanford University, CA 94305, USA; Department of Bioengineering, Stanford University, CA 94305, USA; Department of Neurosurgery, Stanford University, CA 94305, USA; Department of Electrical Engineering, Stanford University, CA 94305, USA. Electronic address: ljinhy@stanford.edu.

Funding

In Vivo Control and Functional Visualization of Stem Cell-Driven CNS RegenerationDP2OD007265 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, JIN HYUNG · 2010 to 2010
$2.4M
Deconstructing Arousal Regulation Circuits for Optimal DBS Therapy DesignR01NS087159 · NINDS · STANFORD UNIVERSITY · PI LEE, JIN HYUNG · 2014 to 2018
$1.9M
Visualization of Neuro-Molecular Targeting using Distribution-Free, High-Res fMRIR00EB008738 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, JIN HYUNG · 2010 to 2012
$745k
NIBIB NIH HHS 4R00EB008738NIBIB NIH HHS R00 EB008738NIH HHS 1DP2OD007265NIH HHS DP2 OD007265NINDS NIH HHS R01 NS087159
6 · The paper itself

Abstract

In vivo imaging is increasingly being utilized in studies investigating stem cell-based treatments for neurological disorders. Direct labeling is used in preclinical and clinical studies to track the fate of transplanted cells. To further determine cell viability, experimental studies are able to take advantage of reporter gene technologies. Structural and functional brain imaging can also be used alongside cell imaging as biomarkers of treatment efficacy. Furthermore, it is possible that new imaging techniques could be used to monitor functional integration of stem cell-derived cells with the host nervous system. In this review, we examine recent developments in these areas and identify promising directions for future research at the interface of stem cell therapies and neuroimaging.

Indexed as

Molecular ImagingStem Cell TransplantationAnimalsBrainHumansStem Cells

Identifiers

PMID25461455
PMCPMC4621007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.