ArticleNanomedicine : nanotechnology, biology, and medicine2015
Bio-inspired hard-to-soft interface for implant integration to bone.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Modulating silver diamine fluoride chemical derivatives by solid-binding peptides.Frontiers in bioengineering and biotechnology · 2026Article
- Machine learning enabled design features of antimicrobial peptides selectively targeting peri-implant disease progression.Frontiers in dental medicine · 2024Article
- Biomedical applications of solid-binding peptides and proteins.Materials today. Bio · 2023Review
- Improving dental epithelial junction on dental implants with bioengineered peptides.Frontiers in bioengineering and biotechnology · 2023Article
- Functionalized 3D-Printed ST2/Gelatin Methacryloyl/Polcaprolactone Scaffolds for Enhancing Bone Regeneration with Vascularization.International journal of molecular sciences · 2022Article
- Bioinspired multifunctional adhesive system for next generation bio-additively designed dental restorations.Journal of the mechanical behavior of biomedical materials · 2021Review
- Harnessing biomolecules for bioinspired dental biomaterials.Journal of materials chemistry. B · 2020Review
- Mitigation of peri-implantitis by rational design of bifunctional peptides with antimicrobial properties.ACS biomaterials science & engineering · 2020Article
- Self Assembled Recombinant Proteins on Metallic Nanoparticles As Bimodal Imaging Probes.JOM (Warrendale, Pa. : 1989) · 2019Article
- Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants.JOM (Warrendale, Pa. : 1989) · 2019Article
- Self-assembling antimicrobial peptides on nanotubular titanium surfaces coated with calcium phosphate for local therapy.Materials science & engineering. C, Materials for biological applications · 2019Article
- Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells.ACS applied materials & interfaces · 2016Article
- Sugary interfaces mitigate contact damage where stiff meets soft.Nature communications · 2016Article
- Controlling the Biomimetic Implant Interface: Modulating Antimicrobial Activity by Spacer Design.Journal of molecular and engineering materials · 2016Article
- Recombinant Amelogenin Protein Induces Apical Closure and Pulp Regeneration in Open-apex, Nonvital Permanent Canine Teeth.Journal of endodontics · 2016Article
- Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats.International journal of nanomedicine · 2016Article
- Chimeric peptides as implant functionalization agents for titanium alloy implants with antimicrobial properties.JOM (Warrendale, Pa. : 1989) · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Accomplishing full, functional integration at the host-to-biomaterial interface has been a critical roadblock in engineering implants with performance similar to biological materials. Molecular recognition-based self-assembly, coupled with biochemical signaling, may lead to controllable and predictable cellular differentiation at the implant interface. Here, we engineer a bio-inspired interface built upon a chimeric peptide. Binding to the biomaterial interface is achieved using a molecular recognition domain specific for the titanium/titanium alloy implant surface and a biochemical signal guiding stem cells to differentiate by activating the Wnt signaling pathway for bone formation. During a critical period of host cell growth and determination, the bioactive implant interface signals mouse, as well as human, stem cells to differentiate along osteogenic lineages. The Wnt-induced cells show enhanced mineral deposition in an extracellular matrix of their creation and an enhanced gene expression profile consistent with osteogenesis, thereby providing a bone-to-implant interface that promotes bone regeneration. FROM THE CLINICAL EDITOR: This team of authors studied methods for enhanced hard-to-soft interface for implant integration to bone, and demonstrate how a bio-inspired surface built upon a chimeric peptide may be utilized for this purpose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.