ArticlePloS one2014
H2O2 inhibits ABA-signaling protein phosphatase HAB1.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- SnRK2s: Kinases or Substrates?Plants (Basel, Switzerland) · 2025Review
- A network-based modeling framework reveals the core signal transduction network underlying high carbon dioxide-induced stomatal closure in guard cells.PLoS biology · 2024Article
- SnRK2.10 kinase differentially modulates expression of hub WRKY transcription factors genes under salinity and oxidative stress inFrontiers in plant science · 2023Article
- Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds.Nature biotechnology · 2022Article
- The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for HNature plants · 2022Article
- The Multifaceted Regulation of SnRK2 Kinases.Cells · 2021Review
- Linking Autophagy to Abiotic and Biotic Stress Responses.Trends in plant science · 2019Review
- Abscisic Acid Inhibits Rice Protein Phosphatase PP45 via HThe Plant cell · 2019Article
- Quantitative Phosphoproteomic and System-Level Analysis of TOR Inhibition Unravel Distinct Organellar Acclimation inFrontiers in plant science · 2018Article
- Short-term effect of elevated COEcology and evolution · 2017Article
- Phosphatase ABI1 and okadaic acid-sensitive phosphoprotein phosphatases inhibit salt stress-activated SnRK2.4 kinase.BMC plant biology · 2016Article
- Changes of Nitric Oxide and Its Relationship with H2O2 and Ca2+ in Defense Interactions between Wheat and Puccinia Triticina.PloS one · 2015Article
- Integration of C/N-nutrient and multiple environmental signals into the ABA signaling cascade.Plant signaling & behavior · 2015Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Due to its ability to be rapidly generated and propagated over long distances, H2O2 is an important second messenger for biotic and abiotic stress signaling in plants. In response to low water potential and high salt concentrations sensed in the roots of plants, the stress hormone abscisic acid (ABA) activates NADPH oxidase to generate H2O2, which is propagated in guard cells in leaves to induce stomatal closure and prevent water loss from transpiration. Using a reconstituted system, we demonstrate that H2O2 reversibly prevents the protein phosphatase HAB1, a key component of the core ABA-signaling pathway, from inhibiting its main target in guard cells, SnRK2.6/OST1 kinase. We have identified HAB1 C186 and C274 as H2O2-sensitive thiols and demonstrate that their oxidation inhibits both HAB1 catalytic activity and its ability to physically associate with SnRK2.6 by formation of intermolecular dimers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.