Trial reportHeart rhythm2015
The effect of reverse remodeling on long-term survival in mildly symptomatic patients with heart failure receiving cardiac resynchronization therapy: results of the REVERSE study.
Trial report in Heart rhythm, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Importance of Implantable Cardioverter-Defibrillator Back-Up in Cardiac Resynchronization Therapy Recipients: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2015Pooled it
- Cardiac resynchronization therapy with or without atrioventricular node ablation in atrial fibrillation: the CAAN-AF trial.European heart journal · 2026Trial
- Effect of Interventricular Electrical Delay on Atrioventricular Optimization for Cardiac Resynchronization Therapy.Circulation. Arrhythmia and electrophysiology · 2018Trial
- Novel measure of electrical dyssynchrony predicts response in cardiac resynchronization therapy: Results from the SMART-AV Trial.Heart rhythm · 2015Trial
- The prognostic significance of serum sodium in a population undergoing cardiac resynchronisation therapy.Indian heart journalTrial
- Pre-Implant Substrate, Peri-Implant Electrical Features, and Outcomes Across Four Echocardiographic Phenotypes After CRT-D.Journal of clinical medicine · 2026Article
- Association of Non-Severe Aortic Stenosis With Left Ventricular Reverse Remodeling and Clinical Outcomes After Cardiac Resynchronization Therapy.Circulation reports · 2026Article
- Novel echocardiographic tools for predicting a good response to cardiac resynchronization therapy: a narrative review.Frontiers in cardiovascular medicine · 2026Review
- Leadless Devices: the Future of Pacing.Current cardiology reports · 2025Review
- Feasibility of totally leadless left bundle branch area pacing via a left endocardial pacing electrode in patients with heart failure: A 3-case series.HeartRhythm case reports · 2025Article
- Obesity paradox in patients with reduced ejection fraction eligible for device implantation - an observational study.ESC heart failure · 2024Observational
- Enhancing patient acceptance of ICD implantation through structured shared decision making: conversation is key.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Cardiac Magnetic Resonance Identifies Responders to Cardiac Resynchronization Therapy with an Assessment of Septal Scar and Left Ventricular Dyssynchrony.Journal of clinical medicine · 2023Article
- Neurohumoral Activation in Heart Failure.International journal of molecular sciences · 2023Review
- Predictive value of global longitudinal strain by left ventricular ejection fraction.ESC heart failure · 2023Article
- Circulating Angiokines Are Associated With Reverse Remodeling and Outcomes in Chronic Heart Failure.Journal of cardiac failure · 2023Article
- 2023 National Heart Center/Saudi Heart Association Focused Update of the 2019 Saudi Heart Association Guidelines for the Management of Heart Failure.Journal of the Saudi Heart Association · 2023Article
- Stratification of Destination Therapy Candidates by J-HeartMate Risk Score Among Elderly Non-Responders to Cardiac Resynchronization Therapy.Circulation reports · 2022Article
- Effect of single ventricular premature contractions on response to cardiac resynchronization therapy.BMC cardiovascular disorders · 2022Article
- Sacubitril-Valsartan, Clinical Benefits and Related Mechanisms of Action in Heart Failure With Reduced Ejection Fraction. A Review.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundCardiac resynchronization therapy (CRT) reduces mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure (HF). The magnitude of reverse remodeling predicts survival with many HF medical therapies. However, there are few studies assessing the effect of remodeling on long-term survival with CRT.
objectiveThe purpose of this study was to assess the effect of CRT-induced reverse remodeling on long-term survival in patients with mildly symptomatic heart failure.
methodsThe REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction trial was a multicenter, double-blind, randomized trial of CRT in patients with mild HF. Long-term follow-up of 5 years was preplanned. The present analysis was restricted to the 353 patients who were randomized to the CRT ON group with paired echocardiographic studies at baseline and 6 months postimplantation. The left ventricular end-systolic volume index (LVESVi) was measured in the core laboratory and was an independently powered end point of the REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction trial.
resultsA 68% reduction in mortality was observed in patients with ≥15% decrease in LVESVi compared to the rest of the patients (P = .0004). Multivariable analysis showed that the change in LVESVi was a strong independent predictor (P = .0002), with a 14% reduction in mortality for every 10% decrease in LVESVi. Other remodeling parameters such as left ventricular end-diastolic volume index and ejection fraction had a similar association with mortality.
conclusionThe change in left ventricular end-systolic volume after 6 months of CRT is a strong independent predictor of long-term survival in mild HF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.