Evidence map›Paper›PMID 25460807›Full record

ReviewCurrent opinion in microbiology2014

RNA polymerase: chromosome domain boundary maker and regulator of supercoil density.

N Patrick Higgins

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Transcription of Bacterial Chromatin.Journal of molecular biology · 2019
    Review
  8. Supercoil Levels inMicroorganisms · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Topological Behavior of Plasmid DNA.Microbiology spectrum · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

N Patrick HigginsDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, United States. nphiggin@uab.edu

Funding

LONG RANGE INTERACTIONS IN MU AND BACTERIAL DNAR01GM033143 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HIGGINS, NORMAN P. · 1985 to 2011
$2.9M
NIGMS NIH HHS GM-33143NIGMS NIH HHS R01 GM033143
6 · The paper itself

Abstract

Most bacterial chromosomes and plasmids are covalently closed circular molecules that are maintained in a dynamic supercoiled state. Average supercoil density differs significantly between Escherichia coli and Salmonella. Two related questions are: What protein(s) create supercoil domain boundaries in a bacterial chromosome? and How is supercoil density regulated in different bacterial species? RNA polymerase plays pivotal roles in both of these topological phenomena.

Indexed as

BacteriaCatalysisChromosomes, BacterialDNA-Directed RNA PolymerasesDNA GyraseDNA, SuperhelicalTranscription Elongation, GeneticDNA-Directed RNA PolymerasesDNA GyraseDNA, SuperhelicalRNA polymerase alpha subunit

Identifiers

PMID25460807
PMCPMC4359758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.