Evidence map›Paper›PMID 25460799›Full record

ReviewCurrent opinion in microbiology2014

Challenges posed by extracellular vesicles from eukaryotic microbes.

Julie M Wolf, Arturo Casadevall

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Gut microbes · 2025
    Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Milk exosomes in nutrition and drug delivery.American journal of physiology. Cell physiology · 2022
    Review
  11. Journal of fungi (Basel, Switzerland) · 2022
    Review
  12. Extracellular Vesicles in the Fungi Kingdom.International journal of molecular sciences · 2021
    Review
  13. Plant-derived xenomiRs and cancer: Cross-kingdom gene regulation.Saudi journal of biological sciences · 2021
    Review
  14. Filamentous Fungi Extracellular Vesicles.Current topics in microbiology and immunology · 2021
    Article
  15. Article
  16. Article
  17. The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020
    Review
  18. Extracellular Vesicles in Fungi: Past, Present, and Future Perspectives.Frontiers in cellular and infection microbiology · 2020
    Review
  19. Extracellular Vesicles-Connecting Kingdoms.International journal of molecular sciences · 2019
    Review
  20. Dietary bovine milk exosomes elicit changes in bacterial communities in C57BL/6 mice.American journal of physiology. Gastrointestinal and liver physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julie M WolfDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, United States
Arturo Casadevall

Funding

Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI052733
6 · The paper itself

Abstract

Extracellular vesicles (EV) produced by eukaryotic microbes play an important role during infection. EV release is thought to benefit microbial invasion by delivering a high concentration of virulence factors to distal host cells or to the cytoplasm of a host cell. EV can significantly impact the outcome of host–pathogen interaction in a cargo-dependent manner. Release of EV from eukaryotic microbes poses unique challenges when compared to their bacterial or archaeal counterparts. Firstly, the membrane-bound organelles within eukaryotes facilitate multiple mechanisms of vesicle generation. Secondly, the fungal cell wall poses a unique barrier between the vesicle release site at the plasma membrane and its destined extracellular environment. This review focuses on these eukaryotic-specific aspects of vesicle synthesis and release.

Indexed as

AnimalsBiological TransportEukaryotaExtracellular SpaceFungiTransport Vesicles

Identifiers

PMID25460799
PMCPMC4359756

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.