ReviewRedox biology2014
Role of sulfiredoxin in systemic diseases influenced by oxidative stress.
Review in Redox biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- The desulfinylation enzyme sulfiredoxin-1 attenuates HSC activation and liver fibrosis by modulating the PTPN12-NLRP3 axis.Hepatology (Baltimore, Md.) · 2025Article
- Comparative Analysis of Immune Response Genes Induced by a Virulent or Attenuated Strain ofInternational journal of molecular sciences · 2025Article
- CRL3Nature communications · 2024Article
- Review
- Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.Journal of gastroenterology · 2023Article
- Sulfiredoxin-1 is a promising novel prognostic biomarker for hepatocellular carcinoma.Cancer medicine · 2020Article
- SRXN1 stimulates hepatocellular carcinoma tumorigenesis and metastasis through modulating ROS/p65/BTG2 signalling.Journal of cellular and molecular medicine · 2020Article
- Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Targeting the Redox Landscape in Cancer Therapy.Cancers · 2020Review
- Cyclic ONeurobiology of aging · 2019Article
- Chemical proteomics reveals new targets of cysteine sulfinic acid reductase.Nature chemical biology · 2018Article
- Expression of thioredoxin, 8Hydroxy-deguanosine and peroxiredoxins in placental tissues.International journal of clinical and experimental pathology · 2017Article
- Sulfiredoxin levels in gingival crevicular fluid: A new antioxidant defence system- case control study.Journal of oral biology and craniofacial researchArticle
- Association of SRXN1 Receptor Gene Polymorphism with Susceptibility to Periodontitis.Contemporary clinical dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sulfiredoxin is a recently discovered member of the oxidoreductases family which plays a crucial role in thiol homoeostasis when under oxidative stress. A myriad of systemic disorders have oxidative stress and reactive oxygen species as the key components in their etiopathogenesis. Recent studies have evaluated the role of this enzyme in oxidative stress mediated diseases such as atherosclerosis, chronic obstructive pulmonary disease and a wide array of carcinomas. Its action is responsible for the normal functioning of cells under oxidative stress and the promotion of cell survival in cancerous cells. This review will highlight the cumulative effects of sulfiredoxin in various systemic disorders with a strong emphasis on its target activity and the factors influencing its expression in such conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.