Evidence map›Paper›PMID 25460571›Full record

ArticleBone2015

Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone.

Ji Wang, Bin Zhou, X Sherry Liu, Aaron J Fields, Arnav Sanyal, Xiutao Shi, Mark Adams, Tony M Keaveny, X Edward Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Musculoskeletal and Marrow Sparing With Proton FLASH Radiation Therapy in Juvenile Mice.International journal of radiation oncology, biology, physics · 2026
    Article
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  8. Review
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  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Raccoons Reveal Hidden Diversity in Trabecular Bone Development.Integrative organismal biology (Oxford, England) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ji WangBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: jw2857@columbia.edu.
Bin ZhouBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: bz2159@columbia.edu.
X Sherry LiuBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA; McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: xiaoweil@mail.med.upenn.edu.
Aaron J FieldsDepartment of Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, USA; Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA. Electronic address: FieldsA@orthosurg.ucsf.edu.
Arnav SanyalDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA. Electronic address: arnavsanyal@berkeley.edu.
Xiutao ShiBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: xs2163@columbia.edu.
Mark AdamsDepartment of Applied Physics and Applied Mathematics, Columbia University, New York, NY, USA. Electronic address: mark.adams@columbia.edu.
Tony M KeavenyDepartment of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA. Electronic address: tmk@me.berkeley.edu.
X Edward GuoBone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA. Electronic address: exg1@columbia.edu.

Funding

Micro-Mechanical Modeling of Trabecular BoneR01AR051376 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GUO, X. EDWARD · 2006 to 2015
$3.2M
Clinical Bone Mechanics Using HR-pQCT and ??MRIR01AR058004 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GUO, X. EDWARD, SHANE, ELIZABETH J · 2010 to 2014
$3.1M
Howard Hughes Medical InstituteNIAMS NIH HHS AR051376NIAMS NIH HHS AR058004NIAMS NIH HHS R01 AR051376NIAMS NIH HHS R01 AR058004
6 · The paper itself

Abstract

The microstructure of trabecular bone is usually perceived as a collection of plate-like and rod-like trabeculae, which can be determined from the emerging high-resolution skeletal imaging modalities such as micro-computed tomography (μCT) or clinical high-resolution peripheral quantitative CT (HR-pQCT) using the individual trabecula segmentation (ITS) technique. It has been shown that the ITS-based plate and rod parameters are highly correlated with elastic modulus and yield strength of human trabecular bone. In the current study, plate-rod (PR) finite element (FE) models were constructed completely based on ITS-identified individual trabecular plates and rods. We hypothesized that PR FE can accurately and efficiently predict elastic modulus and yield strength of human trabecular bone. Human trabecular bone cores from proximal tibia (PT), femoral neck (FN) and greater trochanter (GT) were scanned by μCT. Specimen-specific ITS-based PR FE models were generated for each μCT image and corresponding voxel-based FE models were also generated in comparison. Both types of specimen-specific models were subjected to nonlinear FE analysis to predict the apparent elastic modulus and yield strength using the same trabecular bone tissue properties. Then, mechanical tests were performed to experimentally measure the apparent modulus and yield strength. Strong linear correlations for both elastic modulus (r(2) = 0.97) and yield strength (r(2) = 0.96) were found between the PR FE model predictions and experimental measures, suggesting that trabecular plate and rod morphology adequately captures three-dimensional (3D) microarchitecture of human trabecular bone. In addition, the PR FE model predictions in both elastic modulus and yield strength were highly correlated with the voxel-based FE models (r(2) = 0.99, r(2) = 0.98, respectively), resulted from the original 3D images without the PR segmentation. In conclusion, the ITS-based PR models predicted accurately both elastic modulus and yield strength determined experimentally across three distinct anatomic sites. Trabecular plates and rods accurately determine elastic modulus and yield strength of human trabecular bone.

Indexed as

Elastic ModulusStress, MechanicalAdultAgedAged, 80 and overBone and BonesBone DensityFemaleFemur NeckFinite Element AnalysisHumansImaging, Three-DimensionalMaleMiddle AgedPressureReference ValuesElastic modulusFinite elementIndividual trabecula segmentationMicroarchitecturePlate and rodYield strength

Identifiers

PMID25460571
PMCPMC4282941

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.