ArticlePsychoneuroendocrinology2015
Personality and gene expression: Do individual differences exist in the leukocyte transcriptome?
Article in Psychoneuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Molecular evolution in light of regulatory-coding epistasis.EMBO reports · 2026Review
- Article
- Gene expression networks regulated by human personality.Molecular psychiatry · 2024Review
- Personality and aging-related immune phenotype.Psychoneuroendocrinology · 2023Article
- Article
- Big Five Personality and CTRA gene expression: Lack of association in a midlife sample of US adults (MIDUS-Refresher).Personality and individual differences · 2021Article
- Social regulation of inflammation related gene expression in the multi-ethnic study of atherosclerosis.Psychoneuroendocrinology · 2020Article
- Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus).Scientific reports · 2020Article
- Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.Cell reports · 2019Article
- Associations of Personality Traits With Chronic Low-Grade Inflammation in a Swiss Community Sample.Frontiers in psychiatry · 2019Article
- Posttraumatic Stress Disorder Symptoms, Temperament, and the Pathway to Cellular Senescence.Journal of traumatic stress · 2018Article
- C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review.Frontiers in psychiatry · 2018Article
- Article
- Differentially conserved transcriptomic response to adversity related to self-rated health in the multi-ethnic study of atherosclerosis.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Affective immunology: where emotions and the immune response converge.Dialogues in clinical neuroscience · 2017Review
- Personality and uveitis.Journal of ophthalmic inflammation and infection · 2016Article
- Psychological resilience and the gene regulatory impact of posttraumatic stress in Nepali child soldiers.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Host behaviour-parasite feedback: an essential link between animal behaviour and disease ecology.Proceedings. Biological sciences · 2016Review
- Engaging Patients With Advance Directives Using an Information Visualization Approach.Journal of gerontological nursing · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe temporal and situational stability of personality has led generations of researchers to hypothesize that personality may have enduring effects on health, but the biological mechanisms of such relationships remain poorly understood. In the present study, we utilized a functional genomics approach to examine the relationship between the 5 major dimensions of personality and patterns of gene expression as predicted by 'behavioural immune response' theory. We specifically focussed on two sets of genes previously linked to stress, threat, and adverse socio-environmental conditions: pro-inflammatory genes and genes involved in Type I interferon and antibody responses.
methodsAn opportunity sample of 121 healthy individuals was recruited (86 females; mean age 24 years). Individuals completed a validated measure of personality; questions relating to current health behaviours; and provided a 5ml sample of peripheral blood for gene expression analysis.
resultsExtraversion was associated with increased expression of pro-inflammatory genes and Conscientiousness was associated with reduced expression of pro-inflammatory genes. Both associations were independent of health behaviours, negative affect, and leukocyte subset distributions. Antiviral and antibody-related gene expression was not associated with any personality dimension.
conclusionsThe present data shed new light on the long-observed epidemiological associations between personality, physical health, and human longevity. Further research is required to elucidate the biological mechanisms underlying these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.