Evidence map›Paper›PMID 25459874›Full record

ReviewDevelopmental cognitive neuroscience2015

The potential of infant fMRI research and the study of early life stress as a promising exemplar.

Alice M Graham, Jennifer H Pfeifer, Philip A Fisher, Weili Lin, Wei Gao, Damien A Fair

Abstract readReview
In one paragraph

Review in Developmental cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Longitudinal Changes in Infant Attention-Related Brain Networks and Fearful Temperament.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
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  11. Towards personalized precision functional mapping in infancy.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  12. Review
  13. From behavioral synchrony to language and beyond.Frontiers in integrative neuroscience · 2024
    Review
  14. Article
  15. Article
  16. Review
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  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alice M GrahamDepartment of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: grahaal@ohsu.edu.
Jennifer H PfeiferDepartment of Psychology, University of Oregon, 1715 Franklin Boulevard, Eugene, OR 97403, United States.
Philip A FisherDepartment of Psychology, University of Oregon, 1715 Franklin Boulevard, Eugene, OR 97403, United States.
Weili LinDepartments of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Wei GaoDepartments of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Damien A FairDepartment of Psychology, University of Oregon, 1715 Franklin Boulevard, Eugene, OR 97403, United States; Department of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States; Advanced Imaging Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States.

Funding

Translational Drug Abuse Prevention CenterP50DA035763 · NIDA · OREGON SOCIAL LEARNING CENTER, INC. · PI CHAMBERLAIN, PATRICIA, FISHER, PHILIP A · 2013 to 2017
$9.5M
Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASDR01MH096773 · NIMH · UNIVERSITY OF MINNESOTA · PI DOSENBACH, NICO, FAIR, DAMIEN A · 2012 to 2024
$9.4M
Functional Circuits as an Endophenotype for ADHD in ChildrenR00MH091238 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI FAIR, DAMIEN A · 2011 to 2013
$723k
Early neurobiological predictors of executive functioning in toddlersF32MH105283 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI GRAHAM, ALICE M · 2014 to 2016
$158k
Interparental Conflict And Functional Neural Networks In InfancyF31MH094000 · NIMH · UNIVERSITY OF OREGON · PI GRAHAM, ALICE M · 2011 to 2012
$70k
NIDA NIH HHS P50 DA035763NIMH NIH HHS F31 MH094000NIMH NIH HHS F32 MH105283NIMH NIH HHS R00 MH091238NIMH NIH HHS R01 MH096773PHS HHS F31-10667639
6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI) research with infants and toddlers has increased rapidly over the past decade, and provided a unique window into early brain development. In the current report, we review the state of the literature, which has established the feasibility and utility of task-based fMRI and resting state functional connectivity MRI (rs-fcMRI) during early periods of brain maturation. These methodologies have been successfully applied beginning in the neonatal period to increase understanding of how the brain both responds to environmental stimuli, and becomes organized into large-scale functional systems that support complex behaviors. We discuss the methodological challenges posed by this promising area of research. We also highlight that despite these challenges, early work indicates a strong potential for these methods to influence multiple research domains. As an example, we focus on the study of early life stress and its influence on brain development and mental health outcomes. We illustrate the promise of these methodologies for building on, and making important contributions to, the existing literature in this field.

Indexed as

Magnetic Resonance ImagingBrainChild, PreschoolFemaleHumansInfantMaleNeural PathwaysStress, PsychologicalDevelopmental neuroimagingDevelopmental neuroscienceEarly life stressInfancyNatural sleep fMRIResting state functional connectivity MRI

Identifiers

PMID25459874
PMCPMC4385461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.