ReviewClinics in perinatology2014
Pain management in newborns.
Review in Clinics in perinatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 76 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Using Crochet Octopus in Reducing The Pain Developed During The Process of Heel Lance İn Neonates: A Randomized Controlled Study
The Effect of Reflexology on Pain Management in Newborns: A Randomized-Controlled Clinical Study
Who cites it
76 citing papers in PubMed, 5 syntheses or guidelines pooled it, 270 citations in OpenAlex.
- The comparative efficacy and safety of sweet solutions to reduce preterm infants' pain levels: a systematic review and network meta-analysis.Systematic reviews · 2026Pooled it
- Acupuncture for procedural pain in newborn infants.The Cochrane database of systematic reviews · 2025Pooled it
- Opioid equipotency conversions for hospitalized infants: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2024Pooled it
- Efficacy and safety of vapocoolant spray for vascular puncture in children and adults: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Pooled it
- Oral Melatonin for Pain Relief During Venepuncture in Neonates- a Pilot Randomized Control Trial.European journal of clinical pharmacology · 2025Trial
- The effect of mechanical massage on labor pain, duration and maternal satisfaction: a randomized controlled trial.BMC pregnancy and childbirth · 2025Trial
- The Effect of Auricular Massage on Naso-Oral Suctioning Procedural Pain in Premature Neonates: A Randomized Controlled Crossover Study.TheScientificWorldJournal · 2025Trial
- Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale, near-infrared spectroscopy, and ultrasonography: a randomized trial.World journal of pediatrics : WJP · 2023Trial
- Effect of whole body massage on pain scores of neonates during venous puncture and comparison with oral dextrose and Kangaroo care, a randomized controlled evaluator-blind clinical study.Journal of perinatology : official journal of the California Perinatal Association · 2023Trial
- Intranasal fentanyl for pain management during screening for retinopathy of prematurity in preterm infants: a randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2020Trial
- Analgosedation in Neonatal Intensive Care: Current Strategies, Challenges, and Future Perspectives.Life (Basel, Switzerland) · 2026Review
- Associations between fentanyl exposure, gut microbiome and neurodevelopmental outcomes in preterm infants.Pediatric research · 2026Article
- Use of Tramadol in Pain Management of Neonates with Epidermolysis Bullosa: A Single-Center Experience.Children (Basel, Switzerland) · 2026Article
- Comparison of Low and High Dose Clonidine for Infants Admitted to the Neonatal Intensive Care Unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Pharmacological therapy of neonatal analgosedation: current status, dilemmas, and perspectives.Frontiers in pediatrics · 2026Review
- Adams-Oliver Syndrome: A Comprehensive Literature Review of Clinical, Nutritional, Genetic, and Molecular Aspects with Nursing Care Considerations.International journal of molecular sciences · 2025Review
- Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity.Communications biology · 2025Article
- Continuous wireless sensor monitoring with applied diagnostics: Clinical Sensor Pain Scale and Automated Sensor Pain Scale in the NICU.BMJ health & care informatics · 2025Article
- Neonatal exposure to morphine results in prolonged pain hypersensitivity during adolescence, driven by gut microbial dysbiosis and gut-brain axis-mediated inflammation.Brain, behavior, and immunity · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
As a standard of care for preterm/term newborns effective pain management may improve their clinical and neurodevelopmental outcomes. Neonatal pain is assessed using context-specific, validated, and objective pain methods, despite the limitations of currently available tools. Therapeutic approaches reducing invasive procedures and using pharmacologic, behavioral, or environmental measures are used to manage neonatal pain. Nonpharmacologic approaches like kangaroo care, facilitated tucking, non-nutritive sucking, sucrose, and others can be used for procedural pain or adjunctive therapy. Local/topical anesthetics, opioids, NSAIDs/acetaminophen and other sedative/anesthetic agents can be incorporated into NICU protocols for managing moderate/severe pain or distress in all newborns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.