Evidence map›Paper›PMID 25459576›Full record

ReviewImmunology and allergy clinics of North America2015

Food allergy: epidemiology and natural history.

Jessica Savage, Christina B Johns

Registry-linked trialAbstract readReview
In one paragraph

Review in Immunology and allergy clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06386081 (Dietary Intervention in Food Allergy), which is not on this map. Cited by 118 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06386081 nacompletednot on this mapstarted 2021, after this paper: background citation

Dietary Intervention in Food Allergy: Microbiome, Epigenetic and Metabolomic Interactions

TypeinterventionalSponsorFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludRan2021 to 2023Enrolled51ConditionsFood AllergyArmsCitrus pectin with low DE, Apple pectin with high DE, Placebo
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Daily egg intake may reduce sensitisation to common allergenic foods among six- to nine-month-old south African infants: A randomized controlled trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Article
  12. Review
  13. Article
  14. Objective sensitization algorithm validates parental report of food allergy in children.The journal of allergy and clinical immunology. Global · 2025
    Article
  15. Observational
  16. Article
  17. Food allergens in immune systems.Food science and biotechnology · 2025
    Review
  18. Article
  19. Article
  20. Review

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jessica SavageDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Smith Building, Room 516c, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Smith Building, Room 626, Boston, MA 02215, USA. Electronic address: jrsavage@partners.org.
Christina B JohnsDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Smith Building, Room 516c, Boston, MA 02115, USA.

Funding

Antimicrobial Chemicals in Allergic DiseaseK23AI110522 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SAVAGE, JESSICA R · 2014 to 2016
$552k
NIAID NIH HHS K23 AI110522
6 · The paper itself

Abstract

The prevalence of food allergy is rising for unclear reasons, with prevalence estimates in the developed world approaching 10%. Knowledge regarding the natural course of food allergies is important because it can aid the clinician in diagnosing food allergies and in determining when to consider evaluation for food allergy resolution. Many food allergies with onset in early childhood are outgrown later in childhood, although a minority of food allergy persists into adolescence and even adulthood. More research is needed to improve food allergy diagnosis, treatment, and prevention.

Indexed as

AllergensChildEgg HypersensitivityFood HypersensitivityHumansImmunoglobulin EMilk HypersensitivityNut HypersensitivityPeanut HypersensitivityRisk FactorsWheat HypersensitivityAllergensImmunoglobulin EEggEpidemiologyFood allergyMilkNatural historyPeanut

Identifiers

PMID25459576
PMCPMC4254585

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.