ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2015
Perinatal risk factors for development of celiac disease in children, based on the prospective Norwegian Mother and Child Cohort Study.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Complementary Feeding: Recommendations for the Introduction of Allergenic Foods and Gluten in the Preterm Infant.Nutrients · 2021Pooled it
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- Gastrointestinal consequences of cesarean section birth: A systematic review of short- and long-term effects in infancy and beyond.World journal of clinical pediatrics · 2026Article
- Gastrointestinal morbidity in children whose mothers have anorexia nervosa: A longitudinal cohort study.Psychological medicine · 2025Article
- Prevalence of delivery mode in an Italian nationwide cohort with celiac disease: a SIGENP multicenter retrospective study (the CD-deliver-IT).Italian journal of pediatrics · 2024Article
- Non-Host Factors Influencing Onset and Severity of Celiac Disease.Gastroenterology · 2024Review
- Coeliac disease: what can we learn from prospective studies about disease risk?The Lancet. Child & adolescent health · 2024Review
- Cesarean delivery and risk of hospitalization for autoimmune disorders before 14 years of age.European journal of pediatrics · 2021Article
- Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications.European journal of nutrition · 2020Review
- The Role of Early Programming and Early Nutrition on the Development and Progression of Celiac Disease: A Review.Nutrients · 2020Review
- Celiac Disease and the Microbiome.Nutrients · 2019Review
- Smoking in pregnancy, cord blood cotinine and risk of celiac disease diagnosis in offspring.European journal of epidemiology · 2019Article
- Coeliac disease: beyond genetic susceptibility and gluten. A narrative review.Annals of medicine · 2019Review
- Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study.Journal of pediatric gastroenterology and nutrition · 2018Observational
- Celiac Disease Prevention.Frontiers in pediatrics · 2018Review
- Mode of delivery is not associated with celiac disease.Clinical epidemiology · 2018Article
- Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies.Frontiers in pediatrics · 2018Review
- Diagnosis of celiac disease and applicability of ESPGHAN guidelines in Mediterranean countries: a real life prospective study.BMC gastroenterology · 2017Article
- Birth weight, sex, and celiac disease: a nationwide twin study.Clinical epidemiology · 2017Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
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Abstract
BACKGROUND &
aimsThere have been inconsistent reports of prenatal and perinatal factors that affect risk for development of celiac disease. We assessed the association of fetal growth, birth weight, and mode of delivery with development of celiac disease within the Norwegian Mother and Child (MoBa) Cohort Study.
methodsThe MoBa cohort contains pregnancy information on 95,200 women and data on their 114,500 children, which were collected in Norway from 1999 through 2008; it is linked to the Medical Birth Registry. Women and children with celiac disease were identified from the National Patient Registry and from women's responses to MoBa questionnaires. We calculated odds ratios (ORs) for celiac disease by using a multivariable logistic regression model, adjusting for maternal celiac disease, sex of children, and children's age (model 1); in a second model, we adjusted for age of gluten introduction and duration of breastfeeding (model 2).
resultsWe identified 650 children with celiac disease and 107,828 controls in the MoBa database. We found no association between birth weight or height with celiac disease (born small for gestational age was not associated). Celiac disease was not associated with mode of delivery (cesarean section, model 1: OR, 0.84; 95% confidence interval [CI], 0.65-1.09, and model 2: OR, 0.83; 95% CI, 0.63-1.09). Maternal celiac disease, adjusted for age and sex of the children (OR, 12.45; 95% CI, 8.29-18.71) and type 1 diabetes (model 1: OR, 2.58; 95% CI, 1.19-5.53, and model 2: OR, 2.61; 95% CI, 1.14-5.98) were associated with development of celiac disease in children, whereas maternal type 2 diabetes and gestational diabetes were not.
conclusionsOn the basis of analysis of the Norwegian MoBa cohort, development of celiac disease in children is significantly associated with sex of the child, maternal celiac disease, and type 1 diabetes but not with intrauterine growth.
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