Evidence map›Paper›PMID 25459185›Full record

ReviewHematology/oncology clinics of North America2014

Hematopoietic stem cell transplantation for primary immunodeficiencies.

Elizabeth Kang, Andrew Gennery

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02579967 phase2recruitingnot on this mapstarted 2015, after this paper: background citation

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

TypeinterventionalSponsorNational Cancer Institute (NCI)Ran2015 to 2036Enrolled354ConditionsPrimary T-cell Immunodeficiency Disorders, Common Variable Immunodeficiency, Immune System Diseases, Autoimmune LymphoproliferativeArmsImmunosuppression Only Conditioning -Closed with amendment L, Reduced Intensity Conditioning, Myeloablative Conditioning-Closed with amendment L, GVHD Prophylaxis, Allo BMT
NCT03111745 completednot on this mapstarted 2017, after this paper: background citation

Retrospective Study of Viral Reactivation Across All Bone Marrow Transplant Protocols Since 2010

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2017 to 2020Enrolled730ConditionsViral Infections
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. T-cell frequencies of CD8Bone marrow transplantation · 2019
    Article
  5. Gonadal failure among female patients after hematopoietic stem cell transplantation for non-malignant diseases.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Elizabeth KangHematotherapeutics Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10-CRC Room 6-3752, 10 Centre Drive, Bethesda, MD 20892, USA. Electronic address: ekang@niaid.nih.gov.
Andrew GenneryPaediatric Immunology Department, Institute of Cellular Medicine, Great North Children's Hospital, c/o Ward 3, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.
Great North Children's Hospital · GBNational Institutes of Health · US

Funding

Development and conduct of allogeneic stem cell transplant and autologous stem cell gene therapy for inherited immune deficienciesZIAAI000989 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KANG, ELIZABETH · 2009 to 2025
$12.4M
Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation has been shown to be curative for well-described as well as newly discovered immunodeficiencies. However, it is difficulty to define a universal transplant regimen given the rarity of these disorders and the varied pathophysiology these disorders encompass. This article discusses those primary immunodeficiencies most commonly treated by hematopoietic stem cell transplant and describes the transplant issues specific to these disorders.

Indexed as

Blood DonorsHematopoietic Stem Cell TransplantationHistocompatibility TestingHumansImmunologic Deficiency SyndromesSurvival AnalysisTransplantation, HomologousTreatment OutcomeImmune reconstitutionImmunodeficiencyImmunosuppressionInfectionInflammation

Identifiers

PMID25459185
PMCPMC4255564
OpenAlexW2154997745

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.