Evidence map›Paper›PMID 25459086›Full record

ArticleAnnals of epidemiology2015

Preterm birth and long-term maternal cardiovascular health.

Wei Perng, Jennifer Stuart, Sheryl L Rifas-Shiman, Janet W Rich-Edwards, Alison Stuebe, Emily Oken

Abstract read
In one paragraph

Article in Annals of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei PerngDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA. Electronic address: wei.perng@gmail.com.
Jennifer StuartDepartment of Epidemiology, Harvard School of Public Health, Boston, MA.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Janet W Rich-EdwardsConnors Center for Women's Health, Brigham and Women's Hospital, Boston, MA.
Alison StuebeObstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA; Department of Nutrition, Harvard School of Public Health, Boston, MA.

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
NUTRITION IN PREGNANCY, BIRTH WEIGHT, &CHILDHOOD ASTHMAR01HL064925 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2000 to 2010
$7.5M
Pre- and Peri-natal Predictors of Childhood ObesityR37HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2012 to 2015
$4.5M
Maternal fatty acids, child obesity, and asthma immunityR01HL075504 · NHLBI · HARVARD PILGRIM HEALTH CARE, INC. · PI GILLMAN, MATTHEW W · 2004 to 2007
$2.4M
Patient-oriented Research in Maternal Perinatal Overnutrition and Child AdiposityK24HD069408 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2011 to 2015
$844k
Lactation and diabetes risk factors in womenR21DK073739 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI RICH-EDWARDS, JANET W · 2006 to 2007
$459k
NHLBI NIH HHS R01 HL 064925NHLBI NIH HHS R01 HL064925NHLBI NIH HHS R01 HL 075504NHLBI NIH HHS R01 HL075504NICHD NIH HHS K24 HD069408NICHD NIH HHS R01 HD 034568NICHD NIH HHS R37 HD034568NIDDK NIH HHS P30 DK092924NIDDK NIH HHS R21 DK 073739NIDDK NIH HHS R21 DK073739
6 · The paper itself

Abstract

purposeTo investigate whether preterm birth (PTB) is associated with greater cardiovascular disease (CVD) risk in a longitudinal cohort.

methodsWe examined differences in systolic blood pressure (SBP), diastolic blood pressure, insulin resistance (Homeostatic model assessment of insulin resistance), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein, triglycerides, C-reactive protein, and interleukin 6 at 3 years postpartum between women who delivered preterm (gestation <37 weeks; n = 54) versus term (≥37 weeks; n = 751) using multivariable linear regression. We also assessed relations with body mass index, weight change from prepregnancy, and waist circumference at 3 and 7 years postpartum.

resultsMedian age at enrollment was 33.9 years (range: 16.4-44.9). After adjusting for age, race, prepregnancy body mass index, parity, marital status, education, and SBP during early pregnancy, women with PTB had 3.99 mm Hg (95% confidence interval, 0.82-7.16) higher SBP and 7.01 mg/dL (1.54-12.50) lower HDL than those who delivered at term. The association with SBP was attenuated after accounting for hypertension before or during pregnancy (2.78 mm Hg [-0.30 to 5.87]). PTB was not related to other postpartum outcomes.

conclusionsPTB is related to greater CVD risk by 3 years postpartum as indicated by higher SBP and lower HDL. Although these associations may be due to preexisting conditions exacerbated during pregnancy, PTB may flag high-risk women for more vigilant CVD monitoring and lifestyle interventions.

Indexed as

Maternal WelfarePremature BirthAdolescentAdultBlood PressureBody Mass IndexCardiovascular DiseasesCholesterolC-Reactive ProteinFemaleHumansInfant, NewbornInterleukin-6Longitudinal StudiesMultivariate AnalysisPregnancyCholesterolC-Reactive ProteinInterleukin-6TriglyceridesCardiovascular disease riskHDLHypertensionLongitudinalPreterm birthReproductive-aged womenSBP

Identifiers

PMID25459086
PMCPMC4406400

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.