ReviewCurrent opinion in immunology2014
The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.
Review in Current opinion in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detecting fitness epistasis in recently admixed populations with genome-wide data.BMC genomics · 2020Pooled it
- Accelerated Evolution of Context-Dependent Gene Expression in Primate Immune Cells.bioRxiv : the preprint server for biology · 2026Article
- Targeting Zoonotic Spillover Drivers for Global Pandemic Prevention: A Narrative Review.Microorganisms · 2026Review
- Deciphering the genetic control of immune cell function at single-cell resolution: Disease-Specific Cis-eQTLs analysis of COVID-19.Immunogenetics · 2026Article
- Ancient DNA study provides clues to leprosy susceptibility in medieval Europe.Genome biology · 2026Article
- The association between early-life nutrition and palatine tonsil grading in preschool children: a cross-sectional study.Frontiers in nutrition · 2026Article
- On the topical issue of assisted dying: the insurmountable challenges of human existence, and the right to exit.Frontiers in public health · 2026Article
- Expanding the phenotypic spectrum of PROK2/PROKR2: a recall-by-genotype study.Human genetics · 2025Article
- Pathogen Adaptation of HLA Alleles and Its Correlation with Autoimmune Diseases in the Han Chinese.Genomics, proteomics & bioinformatics · 2025Article
- The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women.Frontiers in immunology · 2025Article
- Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.Nature genetics · 2024Article
- Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease risk.Evolution, medicine, and public health · 2024Review
- Article
- Applying an evolutionary mismatch framework to understand disease susceptibility.PLoS biology · 2023Article
- Mapping interindividual dynamics of innate immune response at single-cell resolution.Nature genetics · 2023Article
- Prioritizing autoimmunity risk variants for functional analyses by fine-mapping mutations under natural selection.Nature communications · 2022Article
- Article
- Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?World journal of gastroenterology · 2022Review
- The evolution of powerful yet perilous immune systems.Trends in immunology · 2022Review
- New insights into human immunity from ancient genomics.Current opinion in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.