ReviewCurrent opinion in immunology2014
I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis.
Review in Current opinion in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Dermis resident macrophages orchestrate localized ILC2 eosinophil circuitries to promote non-healing cutaneous leishmaniasis.Nature communications · 2023Article
- Basophil responses in susceptible AKR mice upon infection with the intestinal helminth parasite Trichuris muris.Parasite immunology · 2023Article
- Article
- Age-dependent NK cell dysfunctions in severe COVID-19 patients.Frontiers in immunology · 2022Article
- Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions.European journal of immunology · 2021Review
- CirculatingInnate immunity · 2021Article
- Friend or foe of innate lymphoid cells in inflammation-associated cardiovascular disease.Immunology · 2021Review
- The role of innate lymphoid cells in selected disease states - cancer formation, metabolic disorder and inflammation.Archives of medical science : AMS · 2021Article
- Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis.Cell reports · 2020Article
- A three course menu for ILC and bystander T cell activation.Current opinion in immunology · 2020Review
- Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development.Annual review of cell and developmental biology · 2019Review
- The Immune Function of Tuft Cells at Gut Mucosal Surfaces and Beyond.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.Nature communications · 2019Article
- Tissue signals imprint ILC2 identity with anticipatory function.Nature immunology · 2018Article
- Characterization and allergic role of IL-33-induced neutrophil polarization.Cellular & molecular immunology · 2018Article
- Article
- Sentinels of the Type 2 Immune Response.Trends in immunology · 2018Review
- MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.The Journal of experimental medicine · 2017Article
- IL-33-Mediated Expansion of Type 2 Innate Lymphoid Cells Protects from Progressive Glomerulosclerosis.Journal of the American Society of Nephrology : JASN · 2017Article
- First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment.Cell reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Innate type 2 immune cells are activated in response to helminths, allergens, and certain types of proteases and particulates. Recently, innate type 2 immune pathways have also been implicated in protective host responses to homeostatic perturbations, such as metabolic dysfunction, atherosclerosis, and tissue injury. In this context, innate type 2 cytokines stimulate local tissues, recruit eosinophils, and alternatively activate macrophages to restore homeostasis. As the major source of innate interleukin (IL)-5 and IL-13, group 2 innate lymphoid cells are positioned to initiate and maintain homeostatic type 2 responses. The absence of exogenous stimuli in these processes implicates endogenous pathways in the activation of type 2 immunity and suggests an alternative evolutionary trajectory for type 2 immunity, apart from its role in response to helminths and allergens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.