ArticleCancer letters2015
MicroRNA-320b promotes colorectal cancer proliferation and invasion by competing with its homologous microRNA-320a.
Article in Cancer letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation.Frontiers in immunology · 2026Article
- miRNA/mRNA analysis of increased TGF-β pathways drive epithelial-mesenchymal transition and regulatory T cell differentiation.bioRxiv : the preprint server for biology · 2025Article
- Urinary exosomal miR-320b as a biomarker of tubular atrophy/interstitial fibrosis in IgA nephropathy patients.American journal of translational research · 2025Article
- Decoding colorectal cancer lung metastasis: a global research odyssey.Frontiers in oncology · 2025Article
- Application of Nanoparticles in the Diagnosis and Treatment of Colorectal Cancer.Anti-cancer agents in medicinal chemistry · 2024Review
- lncRNA ILF3-AS1 promotes proliferation and metastasis of colorectal cancer cells by recruiting histone methylase EZH2.Molecular therapy. Nucleic acids · 2021Article
- MicroRNA 320, an Anti-Oncogene Target miRNA for Cancer Therapy.Biomedicines · 2021Review
- Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis.Cell death & disease · 2021Article
- Differential miRNA Expression in Human Macrophage-Like Cells Infected withJournal of fungi (Basel, Switzerland) · 2021Article
- Hsa_circ_0000231 knockdown inhibits the glycolysis and progression of colorectal cancer cells by regulating miR-502-5p/MYO6 axis.World journal of surgical oncology · 2020Article
- Consistent Estimation of Generalized Linear Models with High Dimensional Predictors via Stepwise Regression.Entropy (Basel, Switzerland) · 2020Article
- mir-320b rs755613466 T>C and mir-27a rs780199251 G>A polymorphisms and the risk of IVF failure in Kurdish women.Molecular biology reports · 2020Article
- Tumor-derived exosomal miRNA-320d as a biomarker for metastatic colorectal cancer.Journal of clinical laboratory analysis · 2019Article
- Neuropilins in the Context of Tumor Vasculature.International journal of molecular sciences · 2019Review
- Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population.Cancer medicine · 2018Article
- Serum levels of miR-320 family members are associated with clinical parameters and diagnosis in prostate cancer patients.Oncotarget · 2018Article
- Article
- Identification of metastasis-associated microRNAs in serum from rectal cancer patients.Oncotarget · 2017Article
- miR-138-5p acts as a tumor suppressor by targeting hTERT in human colorectal cancer.International journal of clinical and experimental pathology · 2017Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Colorectal cancer metastasis is believed to be associated with microRNA dysregulation. However, little is known as to how microRNAs regulate colorectal cancer proliferation, invasion and metastasis. In the present study, we compared the microRNA expression profiles between patients of colorectal cancer at diagnosis with and without liver metastasis. MicroRNA-320b was found to be among those up-regulated in the patient group with metastasis. We subsequently found that microRNA-320b, opposite of its homolog, microRNA-320a that differs by only a single nucleotide, functions in promoting colorectal cancer cell proliferation and invasion. Moreover, we found that overexpression of exogenous microRNA-320b can up-regulate the target genes of microRNA-320a including β-catenin, Neuropilin-1 and Rac-1, which are all known to promote tumor proliferation, invasion and metastasis. These results suggest that microRNA-320b may function in competing with microRNA-320a. Thus, our study has proposed one novel mechanism for controlling colorectal cancer proliferation and invasion through homologous competition between microRNAs. This mechanism may be important for colorectal cancer metastasis.
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