ArticleStem cell reports2014
An expandable, inducible hemangioblast state regulated by fibroblast growth factor.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.eLife · 2021Article
- The hemogenic endothelium: a critical source for the generation of PSC-derived hematopoietic stem and progenitor cells.Cellular and molecular life sciences : CMLS · 2021Review
- FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK.Cellular and molecular life sciences : CMLS · 2021Article
- Transcriptional control of blood cell emergence.FEBS letters · 2019Review
- Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture.FEBS letters · 2019Article
- Expandable Arterial Endothelial Precursors from Human CD34Stem cell reports · 2018Article
- Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program.Journal of visualized experiments : JoVE · 2016Article
- Concise Review: Recent Advances in the In Vitro Derivation of Blood Cell Populations.Stem cells translational medicine · 2016Review
- Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm.Genome biology · 2016Article
- Converting cell fates: generating hematopoietic stem cells de novo via transcription factor reprogramming.Annals of the New York Academy of Sciences · 2016Review
- Making a Hematopoietic Stem Cell.Trends in cell biology · 2016Review
- Lost in translation: pluripotent stem cell-derived hematopoiesis.EMBO molecular medicine · 2015Review
- LMO2 at 25 years: a paradigm of chromosomal translocation proteins.Open biology · 2015Review
- Differentiation of pluripotent stem cells into endothelial cells.Current opinion in hematology · 2015Review
- Defining minimum essential factors to derive highly pure human endothelial cells from iPS/ES cells in an animal substance-free system.Scientific reports · 2015Article
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Authors and funding
6 authors.
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Abstract
During development, the hematopoietic and vascular lineages are thought to descend from common mesodermal progenitors called hemangioblasts. Here we identify six transcription factors, Gata2, Lmo2, Mycn, Pitx2, Sox17, and Tal1, that "trap" murine cells in a proliferative state and endow them with a hemangioblast potential. These "expandable" hemangioblasts (eHBs) are capable, once released from the control of the ectopic factors, to give rise to functional endothelial cells, multilineage hematopoietic cells, and smooth muscle cells. The eHBs can be derived from embryonic stem cells, from fetal liver cells, or poorly from fibroblasts. The eHBs reveal a central role for fibroblast growth factor, which not only promotes their expansion, but also facilitates their ability to give rise to endothelial cells and leukocytes, but not erythrocytes. This study serves as a demonstration that ephemeral progenitor states can be harnessed in vitro, enabling the creation of tractable progenitor cell lines.
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