ArticleMolecular and cellular endocrinology2015
3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma.
Article in Molecular and cellular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- The role of mineralocorticoids and glucocorticoids under the impact of 11β-hydroxysteroid dehydrogenase in human breast lesions.Medical molecular morphology · 2022Article
- The Association of Cholesterol Uptake and Synthesis with Histology and Genotype in Cortisol-Producing Adenoma (CPA).International journal of molecular sciences · 2022Article
- Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway.Biomedicines · 2021Review
- Cellular Senescence in Human Aldosterone-Producing Adrenocortical Cells and Related Disorders.Biomedicines · 2021Article
- Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review.Biomedicines · 2021Review
- Histological Characterization of Aldosterone-producing Adrenocortical Adenomas with Different Somatic Mutations.The Journal of clinical endocrinology and metabolism · 2020Article
- Histopathological Analysis of Tumor Microenvironment and Angiogenesis in Pheochromocytoma.Frontiers in endocrinology · 2020Article
- Tumor Cell Subtypes Based on the Intracellular Hormonal Activity in KCNJ5-Mutated Aldosterone-Producing Adenoma.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells.International journal of molecular sciences · 2018Article
- Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms.Endocrine pathology · 2018Review
- Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells.Hypertension (Dallas, Tex. : 1979) · 2017Review
- Development of monoclonal antibodies against the human 3β-hydroxysteroid dehydrogenase/isomerase isozymes.Steroids · 2017Article
- Histopathological Classification of Cross-Sectional Image-Negative Hyperaldosteronism.The Journal of clinical endocrinology and metabolism · 2017Article
- Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Review
- Immunohistochemistry of the adrenal in primary aldosteronism.Current opinion in endocrinology, diabetes, and obesity · 2016Review
- Intratumoral heterogeneity of steroidogenesis in aldosterone-producing adenoma revealed by intensive double- and triple-immunostaining for CYP11B2/B1 and CYP17.Molecular and cellular endocrinology · 2016Article
- Estimation of the Mechanism of Adrenal Action of Endocrine-Disrupting Compounds Using a Computational Model of Adrenal Steroidogenesis in NCI-H295R Cells.Journal of toxicology · 2016Article
- Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues.Endocrine pathology · 2015Article
- Molecular and Cellular Mechanisms of Aldosterone Producing Adenoma Development.Frontiers in endocrinology · 2015Review
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Authors and funding
19 authors at 5 institutions in 2 countries.
Funding
Abstract
It has become important to evaluate the possible involvement of 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) and 2 (HSD3B2) isoforms in aldosterone-producing adenoma (APA). In this study, we studied 67 and 100 APA cases using real-time quantitative PCR (qPCR) and immunohistochemistry, respectively. Results of qPCR analysis demonstrated that HSD3B2 mRNA was significantly more abundant than HSD3B1 mRNA (P < 0.0001), but only HSD3B1 mRNA significantly correlated with CYP11B2 (aldosterone synthase) mRNA (P <0.0001) and plasma aldosterone concentration (PAC) of the patients (P <0.0001). Results of immunohistochemistry subsequently revealed that HSD3B2 immunoreactivity was detected in the great majority of APA but a significant correlation was also detected between HSD3B1 and CYP11B2 (P <0.0001). In KCNJ5 mutated APA, CYP11B2 mRNA (P <0.0001) and HSD3B1 mRNA (P = 0.011) were significantly higher than those of wild type APA. These results suggest that HSD3B1 is involved in aldosterone production, despite its lower levels of expression compared with HSD3B2, and also possibly associated with KCNJ5 mutation in APA.
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