ArticleJournal of biomechanics2014
Mechanical effects of the surface ectoderm on optic vesicle morphogenesis in the chick embryo.
Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells.Nature biomedical engineering · 2023Article
- The effect of fibre cell remodelling on the power and optical quality of the lens.Journal of the Royal Society, Interface · 2023Article
- Sculpting with stiffness: rigidity as a regulator of morphogenesis.Biochemical Society transactions · 2023Review
- Growth anisotropy of the extracellular matrix shapes a developing organ.Nature communications · 2023Article
- Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- The mechanical forces that shape our senses.Development (Cambridge, England) · 2022Review
- A Chemomechanical Model for Regulation of Contractility in the Embryonic Brain Tube.Journal Of Elasticity · 2021Article
- Biomechanical Force Prediction for Lengthening of Small Intestine during Distraction Enterogenesis.Bioengineering (Basel, Switzerland) · 2020Article
- Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure.Journal of cell science · 2019Article
- The peripheral eye: A neurogenic area with potential to treat retinal pathologies?Progress in retinal and eye research · 2019Review
- How mechanical forces shape the developing eye.Progress in biophysics and molecular biology · 2018Review
- Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis.Journal of visualized experiments : JoVE · 2018Article
- Apoptosis generates mechanical forces that close the lens vesicle in the chick embryo.Physical biology · 2018Article
- Tissue growth constrained by extracellular matrix drives invagination during optic cup morphogenesis.Biomechanics and modeling in mechanobiology · 2016Article
- Systems biology and mechanics of growth.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Precise shaping of the eye is crucial for proper vision. Here, we use experiments on chick embryos along with computational models to examine the mechanical factors involved in the formation of the optic vesicles (OVs), which grow outward from the forebrain of the early embryo. First, mechanical dissections were used to remove the surface ectoderm (SE), a membrane that contacts the outer surfaces of the OVs. Principal components analysis of OV shapes suggests that the SE exerts asymmetric loads that cause the OVs to flatten and shear caudally during the earliest stages of eye development and later to bend in the caudal and dorsal directions. These deformations cause the initially spherical OVs to become pear-shaped. Exposure to the myosin II inhibitor blebbistatin reduced these effects, suggesting that cytoskeletal contraction controls OV shape by regulating tension in the SE. To test the physical plausibility of these interpretations, we developed 2-D finite-element models for frontal and transverse cross-sections of the forebrain, including frictionless contact between the SE and OVs. With geometric data used to specify differential growth in the OVs, these models were used to simulate each experiment (control, SE removed, no contraction). For each case, the predicted shape of the OV agrees reasonably well with experiments. The results of this study indicate that differential growth in the OV and external pressure exerted by the SE are sufficient to cause the global changes in OV shape observed during the earliest stages of eye development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.