Evidence map›Paper›PMID 25458430›Full record

ReviewAutonomic neuroscience : basic & clinical2015

Abnormal neurocirculatory control during exercise in humans with chronic renal failure.

Jeanie Park, Holly R Middlekauff

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Autonomic neuroscience : basic & clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  9. Review
  10. The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Metabolic acidosis augments exercise pressor responses in chronic kidney disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
  16. Review
  17. Article
  18. Baroreflex and neurovascular responses to skeletal muscle mechanoreflex activation in humans: an exercise in integrative physiology.American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Review
  19. Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure.American journal of physiology. Heart and circulatory physiology · 2015
    Review
  20. Resistance exercise for cardiac rehabilitation.Progress in cardiovascular diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jeanie ParkRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Research Service Line, Department of Veterans Affairs Medical Center, Decatur, GA, USA. Electronic address: jeanie.park@emory.edu.
Holly R MiddlekauffCardiology Division, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Emory University · USUniversity of California, Los Angeles · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
The Role of Neurovascular Dysfunction and Oxidative Stress in the Exercise IntoleK23HL098744 · NHLBI · EMORY UNIVERSITY · PI PARK, JEANIE · 2010 to 2014
$668k
NCRR NIH HHS UL1 RR025008NHLBI NIH HHS K23 HL098744
6 · The paper itself

Abstract

Abnormal neurocirculatory control during exercise is one important mechanism leading to exercise intolerance in patients with both end-stage renal disease (ESRD) and earlier stages of chronic kidney disease (CKD). This review will provide an overview of mechanisms underlying abnormal neurocirculatory and hemodynamic responses to exercise in patients with kidney disease. Recent studies have shown that ESRD and CKD patients have an exaggerated increase in blood pressure (BP) during both isometric and rhythmic exercise. Subsequent studies examining the role of the exercise pressor reflex in the augmented pressor response revealed that muscle sympathetic nerve activity (MSNA) was not augmented during exercise in these patients, and metaboreflex-mediated increases in MSNA were blunted, while mechanoreflex-mediated increases were preserved under basal conditions. However, normalizing the augmented BP response during exercise via infusion of nitroprusside (NTP), and thereby equalizing baroreflex-mediated suppression of MSNA, an important modulator of the final hemodynamic response to exercise, revealed that CKD patients had an exaggerated increase in MSNA during isometric and rhythmic exercise. In addition, mechanoreflex-mediated control was augmented, and metaboreceptor blunting was no longer apparent in CKD patients with baroreflex normalization. Factors leading to mechanoreceptor sensitization, and other mechanisms underlying the exaggerated exercise pressor response, such as impaired functional sympatholysis, should be investigated in future studies.

Indexed as

Kidney Failure, ChronicExerciseHemodynamicsHumansMechanoreceptorsMuscle, SkeletalNitroprussideSympathetic Nervous SystemNitroprussideChronic renal failureExerciseSympathetic nerve activity

Identifiers

PMID25458430
PMCPMC4336567
OpenAlexW2062427255

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.