ReviewAutonomic neuroscience : basic & clinical2015
Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure.
Review in Autonomic neuroscience : basic & clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Pooled it
- Voluntary Exercise Prevents Hypertensive Response Sensitization Induced by Angiotensin II.Frontiers in neuroscience · 2022Article
- Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2021Review
- Current concept in the diagnosis, treatment and rehabilitation of patients with congestive heart failure.World journal of cardiology · 2021Review
- Different Intensity Exercise Preconditions Affect Cardiac Function of Exhausted Rats through Regulating TXNIP/TRX/NF-ĸBEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Effect of Exercise Training on Exercise Tolerance and Level of Oxidative Stress for Head and Neck Cancer Patients Following Chemotherapy.Frontiers in oncology · 2020Article
- Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children: the PANIC study.European journal of applied physiology · 2019Article
- ACE2 and ADAM17 Interaction Regulates the Activity of Presympathetic Neurons.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Training heart failure patients with reduced ejection fraction attenuates muscle sympathetic nerve activation during mild dynamic exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- New insights about post-exercise albuminuria in hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
- The effects of different physical activities on atrial fibrillation in patients with hypertension and chronic kidney disease.Kidney research and clinical practice · 2017Article
- The effect of the physical activity on polymorphic premature ventricular complexes in chronic kidney disease.Kidney research and clinical practice · 2017Article
- Exercise training preserves vagal preganglionic neurones and restores parasympathetic tonus in heart failure.The Journal of physiology · 2016Article
- Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics.The Journal of physiology · 2016Review
- Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure.American journal of physiology. Heart and circulatory physiology · 2015Review
- The janus face of stress on reproduction: from health to disease.International journal of endocrinology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The control of sympathetic outflow in the chronic heart failure (CHF) state is markedly abnormal. Patients with heart failure present with increased plasma norepinephrine and increased sympathetic nerve activity. The mechanism for this sympatho-excitation is multiple and varied. Both depression in negative feedback sensory control mechanisms and augmentation of excitatory reflexes contribute to this sympatho-excitation. These include the arterial baroreflex, cardiac reflexes, arterial chemoreflexes and cardiac sympathetic afferent reflexes. In addition, abnormalities in central signaling in autonomic pathways have been implicated in the sympatho-excitatory process in CHF. These mechanisms include increases in central Angiotensin II and the Type 1 receptor, increased in reactive oxygen stress, upregulation in glutamate signaling and NR1 (N-methyl-D-aspartate subtype 1) receptors and others. Exercise training in the CHF state has been shown to reduce sympathetic outflow and result in increased survival and reduced cardiac events. Exercise training has been shown to reduce central Angiotensin II signaling including the Type 1 receptor and reduce oxidative stress by lowering the expression of many of the subunits of NADPH oxidase. In addition, there are profound effects on the central generation of nitric oxide and nitric oxide synthase in sympatho-regulatory areas of the brain. Recent studies have pointed to the balance between Angiotensin Converting Enzyme (ACE) and ACE2, translating into Angiotensin II and Angiotensin 1-7 as important regulators of sympathetic outflow. These enzymes appear to be normalized following exercise training in CHF. Understanding the precise molecular mechanisms by which exercise training is sympatho-inhibitory will uncover new targets for therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.