ArticleJournal of biomechanics2014
The effects of tensile-compressive loading mode and microarchitecture on microdamage in human vertebral cancellous bone.
Article in Journal of biomechanics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- An osteoporotic bone model: developing and validating an ex-vivo bone demineralization protocol.JBMR plus · 2026Article
- A 50-year perspective on the use and potential of artiodactyl calcanei in bone adaptation studies.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Microdamage in biological hard tissues and its repair mechanisms.Biomedical engineering online · 2025Review
- Mechanically induced histochemical and structural damage in the annulus fibrosus and cartilaginous endplate: a multi-colour immunofluorescence analysis.Cell and tissue research · 2022Article
- Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in Cancellous Bone From Men With Type 2 Diabetes Mellitus.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Self-reported sleep characteristics and risk for incident vertebral and hip fracture in women.Sleep health · 2022Article
- Obstructive Sleep Apnea and Risk for Incident Vertebral and Hip Fracture in Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Standardizing compression testing for measuring the stiffness of human bone.Bone & joint research · 2018Article
- Bone marrow lesions in osteoarthritis: What lies beneath.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Bone Mechanical Properties in Healthy and Diseased States.Annual review of biomedical engineering · 2018Review
- Using Non-linear Homogenization to Improve the Performance of Macroscopic Damage Models of Trabecular Bone.Frontiers in physiology · 2018Article
- Thiazides and Osteoporotic Spinal Fractures: A Suspected Linkage Investigated by Means of a Two-Center, Case-Control Study.Journal of clinical medicine research · 2017Article
- Effect of including damage at the tissue level in the nonlinear homogenisation of trabecular bone.Biomechanics and modeling in mechanobiology · 2017Article
- Diuretic Use and Risk of Vertebral Fracture in Women.The American journal of medicine · 2016Article
- The roles of architecture and estrogen depletion in microdamage risk in trabecular bone.Journal of biomechanics · 2016Article
- Seeing through Musculoskeletal Tissues: Improving In Situ Imaging of Bone and the Lacunar Canalicular System through Optical Clearing.PloS one · 2016Article
- Article
- Finite element models predict the location of microdamage in cancellous bone following uniaxial loading.Journal of biomechanics · 2015Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
The amount of microdamage in bone tissue impairs mechanical performance and may act as a stimulus for bone remodeling. Here we determine how loading mode (tension vs. compression) and microstructure (trabecular microarchitecture, local trabecular thickness, and presence of resorption cavities) influence the number and volume of microdamage sites generated in cancellous bone following a single overload. Twenty paired cylindrical specimens of human vertebral cancellous bone from 10 donors (47–78 years) were mechanically loaded to apparent yield in either compression or tension, and imaged in three dimensions for microarchitecture and microdamage (voxel size 0.7×0.7×5.0 μm3). We found that the overall proportion of damaged tissue was greater (p=0.01) for apparent tension loading (3.9±2.4%, mean±SD) than for apparent compression loading (1.9±1.3%). Individual microdamage sites generated in tension were larger in volume (p<0.001) but not more numerous (p=0.64) than sites in compression. For both loading modes, the proportion of damaged tissue varied more across donors than with bone volume fraction, traditional measures of microarchitecture (trabecular thickness, trabecular separation, etc.), apparent Young׳s modulus, or strength. Microdamage tended to occur in regions of greater trabecular thickness but not near observable resorption cavities. Taken together, these findings indicate that, regardless of loading mode, accumulation of microdamage in cancellous bone after monotonic loading to yield is influenced by donor characteristics other than traditional measures of microarchitecture, suggesting a possible role for tissue material properties.
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