ArticleNeuropharmacology2015
Activation of 5-HT2a receptors in the basolateral amygdala promotes defeat-induced anxiety and the acquisition of conditioned defeat in Syrian hamsters.
Article in Neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- A Complex Impact of Systemically Administered 5-HT2A Receptor Ligands on Conditioned Fear.The international journal of neuropsychopharmacology · 2021Article
- Pivotal mental states.Journal of psychopharmacology (Oxford, England) · 2021Review
- Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Basolateral Amygdala Serotonin 2C Receptor Regulates Emotional Disorder-Related Symptoms Induced by Chronic Methamphetamine Administration.Frontiers in pharmacology · 2021Article
- Amygdala volume and social anxiety symptom severity: Does segmentation technique matter?Psychiatry research. Neuroimaging · 2020Article
- Regulation of GABAFrontiers in pharmacology · 2020Article
- Expression of serotonin 2A, 2C, 6 and 7 receptor and IL-6 mRNA in experimental toxoplasmic encephalitis in mice.Heliyon · 2019Article
- The negative effects of social bond disruption are partially ameliorated by sertraline administration in prairie voles.Autonomic neuroscience : basic & clinical · 2019Article
- Spaced Training Enhances Contextual Fear MemoryFrontiers in molecular neuroscience · 2019Article
- Serotonin Mediates Depression of Aggression After Acute and Chronic Social Defeat Stress in a Model Insect.Frontiers in behavioral neuroscience · 2018Article
- Metabolomics reveals distinct neurochemical profiles associated with stress resilience.Neurobiology of stress · 2017Article
- Dominance status alters restraint-induced neural activity in brain regions controlling stress vulnerability.Physiology & behavior · 2017Article
- Synthetic cathinones and stereochemistry: S enantiomer of mephedrone reduces anxiety- and depressant-like effects in cocaine- or MDPV-abstinent rats.Drug and alcohol dependence · 2017Article
- Inhibition of vasopressin V1a receptors in the medioventral bed nucleus of the stria terminalis has sex- and context-specific anxiogenic effects.Neuropharmacology · 2016Article
- MATSAP: An automated analysis of stretch-attend posture in rodent behavioral experiments.Scientific reports · 2016Article
- Proteolytic cleavage of proBDNF into mature BDNF in the basolateral amygdala is necessary for defeat-induced social avoidance.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Species differences in behavior and cell proliferation/survival in the adult brains of female meadow and prairie voles.Neuroscience · 2016Article
- Neurobiological mechanisms supporting experience-dependent resistance to social stress.Neuroscience · 2015Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Conditioned defeat is a model in Syrian hamsters (Mesocricetus auratus) in which normal territorial aggression is replaced by increased submissive and defensive behavior following acute social defeat. The conditioned defeat response involves both a fear-related memory for a specific opponent as well as anxiety-like behavior indicated by avoidance of novel conspecifics. We have previously shown that systemic injection of a 5-HT2a receptor antagonist reduces the acquisition of conditioned defeat. Because neural activity in the basolateral amygdala (BLA) is critical for the acquisition of conditioned defeat and BLA 5-HT2a receptors can modulate anxiety but have a limited effect on emotional memories, we investigated whether 5-HT2a receptor modulation alters defeat-induced anxiety but not defeat-related memories. We injected the 5-HT2a receptor antagonist MDL 11,939 (0 mM, 1.7 mM or 17 mM) or the 5-HT2a receptor agonist TCB-2 (0 mM, 8 mM or 80 mM) into the BLA prior to social defeat. We found that injection of MDL 11,939 into the BLA impaired acquisition of the conditioned defeat response and blocked defeat-induced anxiety in the open field, but did not significantly impair avoidance of former opponents in the Y-maze. Furthermore, we found that injection of TCB-2 into the BLA increased the acquisition of conditioned defeat and increased anxiety-like behavior in the open field, but did not alter avoidance of former opponents. Our data suggest that 5-HT2a receptor signaling in the BLA is both necessary and sufficient for the development of conditioned defeat, likely via modulation of defeat-induced anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.