ArticleBiological psychology2014
A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.
Article in Biological psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
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- Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.Frontiers in genetics · 2018Article
- Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress.Psychoneuroendocrinology · 2017Article
- The Trier Social Stress Test: Principles and practice.Neurobiology of stress · 2017Review
- Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress I: Effects in males and females.Psychoneuroendocrinology · 2016Article
- Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression.Journal of abnormal psychology · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (SNP), rs6318 on the HTR2C gene located on the X-chromosome, is associated with hypothalamic-pituitary-adrenal axis response to a laboratory stress recall task. The present paper reports a validation of the cortisol response to stress in a second, independent sample. The study population consisted of 60 adult participants (73.3% males). Consistent with our prior findings, compared to Cys23 G allele carriers, persons homozygous for the Ser23C allele had a significantly greater average cortisol response (p=0.007) and area under the curve (p=0.021) over the course of an emotional stress recall protocol. Also parallel to our prior report, the change in cortisol from baseline to the average during the stress protocol was roughly twice as large among Ser23C homozygotes than among persons with Cys23 G. These findings validate our initial observation of association between rs6318 and cortisol response to an acute stressor, and extend the results to include females.
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