ArticleEuropean journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery2015
Detection of Peripheral Arterial Disease Within the Foot Using Vascular Optical Tomographic Imaging: A Clinical Pilot Study.
Article in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 31 citations in OpenAlex.
- Assessing hemodynamic changes in diabetic patients with and without peripheral arterial disease using dynamic vascular optical spectroscopy.Biomedical engineering online · 2026Article
- Preliminary Study Using Wearable Near-Infrared Spectroscopy for Continuous Monitoring of Hemodynamics Through the Carotid Artery.Biosensors · 2025Article
- Evaluating hemodynamic response to treatment in patients with peripheral arterial disease using dynamic vascular optical spectroscopy.Journal of biomedical optics · 2024Article
- Spatial-Temporal Oxygenation Mapping Using a Near-Infrared Optical Scanner: Towards Peripheral Vascular Imaging.Annals of biomedical engineering · 2023Article
- Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy.Journal of biomedical optics · 2022Article
- Measurement of Revascularization Effect Using Near Infrared Spectroscopy in Below the Knee Arteries.Reviews in cardiovascular medicine · 2022Article
- Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study.Annals of translational medicine · 2021Article
- Modeling of the hemodynamics in the feet of patients with peripheral artery disease.Biomedical optics express · 2019Article
- Photoacoustic computed tomography of human extremities.Journal of biomedical optics · 2019Article
- Non-contact dynamic diffuse optical tomography imaging system for evaluating lower extremity vasculature.Biomedical optics express · 2018Article
- Direct approach to compute Jacobians for diffuse optical tomography using perturbation Monte Carlo-based photon "replay".Biomedical optics express · 2018Article
- Peripheral vascular disease assessment in the lower limb: a review of current and emerging non-invasive diagnostic methods.Biomedical engineering online · 2018Review
- Chromophore decomposition in multispectral time-resolved diffuse optical tomography.Biomedical optics express · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveVascular optical tomographic imaging (VOTI) is a novel imaging modality that is capable of detecting hemoglobin concentrations in tissue. VOTI is non-invasive, non-ionizing and does not require contrast injection. This technology was applied to the diagnosis of peripheral arterial disease (PAD) within lower extremities of diabetic patients with calcified arteries. This could be of substantial benefit as these patients suffer from comorbidities such as arterial incompressibility, which complicates diagnosis and monitoring.
methodsForty individuals (10 non-diabetic patients with PAD, 10 diabetic patients with PAD, and 20 healthy volunteers) were enrolled in a diagnostic pilot study using the VOTI system. The patients were imaged during at high pressure cuff occlusion.
resultsThe VOTI system was capable of quantifying the blood volume changes within the foot during the thigh cuff occlusion and outputting diagnostic parameters, such as change in hemoglobin concentration, enabling the assessment of foot perfusion. This study resulted in a statistically significant difference between the healthy cohort and both the non-diabetic and the diabetic PAD cohorts (p = .006, p = .006). Receiver operating characteristic (ROC) curve analysis showed that PAD diagnosis could be made with over 80% sensitivity or specificity depending on the characteristic cutoff point. In addition, VOTI was capable of providing the locations of under-perfused regions within the foot and evaluating the severity of arterial disease, even within diabetic patients with calcified arteries, who are traditionally difficult to diagnose.
conclusionVOTI can effectively diagnose PAD independently of arterial compressibility, making it very useful for assessing vascular disease in diabetic patients.
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