ArticleChemistry & biology2014
Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers.
Article in Chemistry & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- FDA Drug Repurposing Uncovers Modulators of Dopamine DJournal of medicinal chemistry · 2025Article
- Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer's Disease.International journal of molecular sciences · 2024Article
- Calcium-Associated Proteins in Neuroregeneration.Biomolecules · 2024Review
- Significant Functional Differences Between Dopamine DMolecular neurobiology · 2023Article
- Adenosinergic Pathway in Parkinson's Disease: Recent Advances and Therapeutic Perspective.Molecular neurobiology · 2023Review
- GPCR heteromers: An overview of their classification, function and physiological relevance.Frontiers in endocrinology · 2022Review
- Experimental Evidence of AFrontiers in physiology · 2021Article
- Calcium Sensors in Neuronal Function and Dysfunction.Cold Spring Harbor perspectives in biology · 2019Review
- Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Adenosine AMolecular neurobiology · 2019Article
- Caldendrin and Calneurons-EF-Hand CaM-Like Calcium Sensors With Unique Features and Specialized Neuronal Functions.Frontiers in molecular neuroscience · 2019Review
- Homocysteine and A2A-D2 Receptor-Receptor Interaction at Striatal Astrocyte Processes.Journal of molecular neuroscience : MN · 2018Article
- GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase.Nature communications · 2018Article
- Dopamine D2 Receptors Dimers: How can we Pharmacologically Target Them?Current neuropharmacology · 2018Review
- Receptor-Receptor Interactions of G Protein-Coupled Receptors in the Carotid Body: A Working Hypothesis.Frontiers in physiology · 2018Article
- Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine AFrontiers in pharmacology · 2018Article
- Neuronal Calcium and cAMP Cross-Talk Mediated by Cannabinoid CBFrontiers in cell and developmental biology · 2018Article
- Article
- A Dual Role Hypothesis of the Cortico-Basal-Ganglia Pathways: Opponency and Temporal Difference Through Dopamine and Adenosine.Frontiers in neural circuits · 2018Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The pharmacological significance of the adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromer is well established and it is being considered as an important target for the treatment of Parkinson’s disease and other neuropsychiatric disorders. However, the physiological factors that control its distinctive biochemical properties are still unknown. We demonstrate that different intracellular Ca2+ levels exert a differential modulation of A2AR-D2R heteromer-mediated adenylyl-cyclase and MAPK signaling in striatal cells. This depends on the ability of low and high Ca2+ levels to promote a selective interaction of the heteromer with the neuronal Ca2+-binding proteins NCS-1 and calneuron-1, respectively. These Ca2+-binding proteins differentially modulate allosteric interactions within the A2AR-D2R heteromer, which constitutes a unique cellular device that integrates extracellular (adenosine and dopamine) and intracellular (Ca+2) signals to produce a specific functional response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.