ArticleChemistry & biology2014
N-terminal ArgD peptides from the classical Staphylococcus aureus Agr system have cytotoxic and proinflammatory activities.
Article in Chemistry & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Determinants of maturation of theJournal of bacteriology · 2024Article
- Quorum-sensing, intra- and inter-species competition in the staphylococci.Microbiology (Reading, England) · 2023Review
- Chemical and biomolecular insights into theIsrael journal of chemistry · 2023Article
- Molecular Prerequisites for Neutrophil Extracellular Trap Formation and Evasion Mechanisms ofFrontiers in immunology · 2022Review
- [Significance of neutrophil extracellular trap and its markers in the early diagnosis of community-acquired pneumonia in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Article
- Group A Streptococcal M1 Protein Provides Resistance against the Antimicrobial Activity of Histones.Scientific reports · 2017Article
- Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites.Natural product reports · 2017Review
- Phenol-Soluble Modulin α Peptide Toxins from AggressiveFrontiers in immunology · 2017Article
- Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.Frontiers in immunology · 2017Review
- Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles.Cell chemical biology · 2016Review
- Formation of Neutrophil Extracellular Traps under Low Oxygen Level.Frontiers in immunology · 2016Article
- A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination.Frontiers in immunology · 2016Article
- Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact for the Infected Host.Frontiers in microbiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
AgrD is the precursor for the autoinducing peptide in a quorum-sensing system regulating virulence phenotypes of the preeminent pathogen Staphylococcus aureus. Mass spectrometry-based methods, including molecular networking, identified formylated and nonformylated peptide variants derived from the AgrD N-terminal leader domain in S. aureus cell-free culture supernatants. Functional assessment of these peptides revealed unexpected bioactivities, including human cell-line cytotoxicity, modulation of neutrophil chemotaxis, neutrophil extracellular trap formation, and the aggravation of skin lesions in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.