Evidence map›Paper›PMID 25456761›Full record

ReviewJournal of the American College of Cardiology2014

Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction.

Robert J Mentz, Jacob P Kelly, Thomas G von Lueder, Adriaan A Voors, Carolyn S P Lam, Martin R Cowie, Keld Kjeldsen, Ewa A Jankowska, Dan Atar, Javed Butler and 4 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298825 (Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure), which is not on this map. Cited by 254 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06298825 unknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Sarcopenia on Prognosis of Patients With Acute Decompensated Heart Failure: a Prospective, Multi-center, Observational Cohort Study

TypeobservationalSponsorGuangdong Provincial People's HospitalRan2024 to 2026Enrolled500ConditionsAcute Decompensated Heart Failure
3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  3. Dapagliflozin in Heart Failure: A Comprehensive Meta-analysis on Functional Capacity, Symptoms, and Safety Outcomes.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
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  4. Role of dietary sodium restriction in chronic heart failure: systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
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194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Robert J MentzDuke University, Durham, North Carolina. Electronic address: robert.mentz@duke.edu.
Jacob P KellyDuke University, Durham, North Carolina.
Thomas G von LuederOslo University Hospital Ulleval, University of Oslo, and Institute of Clinical Sciences, University of Oslo, Oslo, Norway.
Adriaan A VoorsUniversity of Groningen, Groningen, the Netherlands.
Carolyn S P LamFramingham Heart Study, Framingham, Boston University School of Medicine, Boston, Massachusetts.
Martin R CowieNational Heart and Lung Institute, Imperial College and Imperial College London, Royal Brompton Hospital, London, United Kingdom.
Keld KjeldsenCopenhagen University Hospital (Rigshospitalet), Copenhagen, and Aalborg University, Aalborg, Denmark.
Ewa A JankowskaDepartment of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Dan AtarOslo University Hospital Ulleval, University of Oslo, and Institute of Clinical Sciences, University of Oslo, Oslo, Norway.
Javed ButlerEmory University, Atlanta, Georgia.
Mona FiuzatDuke University, Durham, North Carolina.
Faiez ZannadINSERM, Centre d'Investigations Cliniques, Université de Lorraine and CHU de Nancy, Nancy, France.
Bertram PittUniversity of Michigan School of Medicine, Ann Arbor, Michigan.
Christopher M O'ConnorDuke University, Durham, North Carolina.

Funding

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program-Evaluation SupplementT32GM086330 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM L.R. BROUWER, Daniel Gonzalez · 2011 to 2026
$8.5M
NIGMS NIH HHS T32 GM086330NIGMS NIH HHS T32GM086330
6 · The paper itself

Abstract

Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF). Although patients with heart failure commonly have multiple comorbidities that complicate management and may adversely affect outcomes, their role in the HFpEF and HFrEF groups is not well-characterized. This review summarizes the role of noncardiac comorbidities in patients with HFpEF versus HFrEF, emphasizing prevalence, underlying pathophysiologic mechanisms, and outcomes. Pulmonary disease, diabetes mellitus, anemia, and obesity tend to be more prevalent in HFpEF patients, but renal disease and sleep-disordered breathing burdens are similar. These comorbidities similarly increase morbidity and mortality risk in HFpEF and HFrEF patients. Common pathophysiologic mechanisms include systemic and endomyocardial inflammation with fibrosis. We also discuss implications for clinical care and future HF clinical trial design. The basis for this review was discussions between scientists, clinical trialists, and regulatory representatives at the 10th Global CardioVascular Clinical Trialists Forum.

Indexed as

Age FactorsAnemiaArthritisComorbidityDiabetes MellitusHeart FailureHumansKidney DiseasesMobility LimitationObesityPulmonary Disease, Chronic ObstructiveRacial GroupsSex FactorsSleep Apnea SyndromesStroke Volumecomorbiditiesejection fractionheart failure

Identifiers

PMID25456761
PMCPMC4254505

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.