Evidence map›Paper›PMID 25456330›Full record

ArticleDrug and alcohol dependence2014

Prenatal cocaine exposure and age of sexual initiation: direct and indirect effects.

Natacha De Genna, Lidush Goldschmidt, Gale A Richardson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Substance Use in the Perinatal Period.Current psychiatry reports · 2015
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Natacha De GennaUniversity of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, United States.
Lidush GoldschmidtUniversity of Pittsburgh Medical Center, Program in Epidemiology, 3811 O'Hara Street, Pittsburgh, PA 15213, United States.
Gale A RichardsonUniversity of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, United States. Electronic address: gar@pitt.edu.
University of Pittsburgh · US

Funding

PRENATAL COCAINE USE--7 YEAR FOLLOW UPR01DA008916 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICHARDSON, GALE A. · 1995 to 2018
$6.4M
PRENATAL COCAINE USE--10 YEAR FOLLOW UPR01DA012401 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICHARDSON, GALE A. · 1999 to 2003
$1.1M
Substance Use and Risky Sex in Highly Vulnerable PopulationsK01DA025734 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DE GENNA, NATACHA · 2009 to 2013
$704k
PRENATAL COCAINE USE: A LONGITUDINAL EPIDEMIOLOGIC STUDYR01DA006839 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICHARDSON, GALE A. · 1991 to 1994
–
EFFECT OF PRENATAL COCAINE USE ON INFANT OUTCOMER29DA005460 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICHARDSON, GALE A. · 1988 to 1992
–
NIDA NIH HHS DA025734NIDA NIH HHS DA06839NIDA NIH HHS DA08916NIDA NIH HHS DA12401NIDA NIH HHS K01 DA025734NIDA NIH HHS R01 DA008916NIDA NIH HHS R01 DA012401NIDA NIH HHS R29 DA005460
6 · The paper itself

Abstract

backgroundPrenatal cocaine exposure (PCE) has been linked to child behavior problems and risky behavior during adolescence such as early substance use. Behavior problems and early substance use are associated with earlier initiation of sexual behavior. The goal of this study was to examine the direct and indirect effects of PCE on sexual initiation in a longitudinal birth cohort, about half of whom were exposed to cocaine in utero.

methodsWomen were interviewed twice prenatally, at delivery, and 1, 3, 7, 10, 15, and 21 years postpartum. Offspring (52% female, 54% African American) were assessed at delivery and at each follow-up phase with age-appropriate assessments. At age 21, 225 offspring reported on their substance use and sexual behavior.

resultsFirst trimester cocaine exposure was a significant predictor of earlier age of first intercourse in a survival analysis, after controlling for race, sociodemographic characteristics, caregiver pre- and postnatal substance use, parental supervision, and child's pubertal timing. However, the association between PCE and age of first sexual intercourse was mediated by adolescent marijuana and alcohol use prior to age 15.

conclusionsMost of the effect of PCE on age of sexual initiation occurred between the ages of 13-18, when rates of initiation were approximately 10% higher among exposed offspring. This effect was mediated by early adolescent substance use. These results have implications for identification of the exposed offspring at greatest risk of HIV risk behaviors and early, unplanned pregnancy.

Indexed as

AdolescentAdultBlack or African AmericanChildCocaineFemaleFollow-Up StudiesHumansLongitudinal StudiesMalePregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk-TakingSexual BehaviorWhite PeopleCocaineAdolescent behaviorMarijuanaPrenatal cocaineSexual behaviorSexual intercourse

Identifiers

PMID25456330
PMCPMC4254808
OpenAlexW1998650800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.