ArticleDrug and alcohol dependence2014
Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain.
Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Developing a novel treatment for patients with chronic pain and Opioid User Disorder.Substance abuse treatment, prevention, and policy · 2022Trial
- Pain and treatment outcomes after initiating methadone vs buprenorphine among medicare patients with opioid use disorder and comorbid chronic pain: A target trial emulation.PLoS medicine · 2026Article
- Associations of discomfort intolerance, discomfort avoidance, and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for opioid use disorder.Drug and alcohol dependence · 2024Article
- Barriers, perceived benefits and preferences to exercise in adults with an opioid use disorder in the U.S.Preventive medicine reports · 2023Article
- Opioid Use Disorder and Racial/Ethnic Health Disparities: Prevention and Management.Current pain and headache reports · 2022Review
- Association between recent overdose and chronic pain among individuals in treatment for opioid use disorder.PloS one · 2022Article
- The relationship between sleep and opioids in chronic pain patients.Journal of behavioral medicine · 2021Article
- Increased Experimental Pain Sensitivity in Chronic Pain Patients Who Developed Opioid Use Disorder.The Clinical journal of pain · 2020Article
- I'm tired and it hurts! Sleep quality and acute pain response in a chronic pain population.Sleep medicine · 2020Article
- Aerobic Exercise Interventions for Patients in Opioid Maintenance Treatment: A Systematic Review.Substance abuse : research and treatment · 2020Review
- The Mesolimbic Dopamine System in Chronic Pain and Associated Affective Comorbidities.Biological psychiatry · 2020Review
- Perioperative Management of Buprenorphine: Solving the Conundrum.Pain medicine (Malden, Mass.) · 2019Review
- Psycho-physiological response to pain among individuals with comorbid pain and opioid use disorder: Implications for patients with prolonged abstinence.The American journal of drug and alcohol abuse · 2019Article
- Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity.Scientific reports · 2018Article
- Opioid Use Disorders: Perioperative Management of a Special Population.Anesthesia and analgesia · 2018Review
- Case Series of Successful Postoperative Pain Management in Buprenorphine Maintenance Therapy Patients.Anesthesia and analgesia · 2017Article
- Hepatitis C virus infection and pain sensitivity in patients on methadone or buprenorphine maintenance therapy for opioid use disorders.Drug and alcohol dependence · 2015Article
- Distress Tolerance in the Comorbid Chronic Pain and Opioid Use Disorder Population.Journal of addiction medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionMedication assisted treatment for opioid dependence alters the pain experience. This study will evaluate changes pain sensitivity and tolerance with opioid treatments; and duration of this effect after treatment cessation.
method120 Individuals with chronic pain were recruited in 4 groups (N = 30): 1-methadone for opioid addiction; 2-buprenorphine for opioid addiction; 3-history of opioid maintenance treatment for opioid addiction but with prolonged abstinence (M = 121 weeks; SD = 23.3); and 4-opioid naïve controls. Participants completed a psychological assessment and a cold water task including, time to first pain (sensitivity) and time to stopping the pain task (tolerance). Data analysis used survival analyses.
resultsA Kaplan-Meier-Cox survival analysis showed group differences for both pain sensitivity (log rank = 15.50; p < .001) and tolerance (log rank = 20.11; p < .001). Current or historical use of opioid maintenance resulted in differing pain sensitivity compared to opioid naïve (p's < .01). However, tolerance to pain was better among those with a history of opioid maintenance compared to active methadone patients (p < .05), with the highest tolerance found among opioid naïve control group participants (p's < .001). Correlations within the prolonged abstinent group indicated pain tolerance was significantly improved as length of opioid abstinence increased (R = .37; p < .05); but duration of abstinence did not alter sensitivity (ns).
conclusionAmong individuals with a history of prolonged opioid maintenance, there appears to be long-term differences in pain sensitivity that do not resolve with discontinuation of opioid maintenance. Although pain sensitivity does not change, pain tolerance does improve after opioid maintenance cessation. Implications for treating co-morbid opioid addiction and pain (acute and chronic) are discussed.
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Registered trials
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