Evidence map›Paper›PMID 25456122›Full record

ArticleCell reports2014

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells.

Catalin Chimerel, Edward Emery, David K Summers, Ulrich Keyser, Fiona M Gribble, Frank Reimann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 312 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
312citing papers in PubMed, 6 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

312 citing papers in PubMed, 6 syntheses or guidelines pooled it, 527 citations in OpenAlex.

  1. Pooled it
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  15. The Gut Microbiome-Endocrine Axis in Obesity: Mechanisms and Therapeutics.Journal of gastroenterology and hepatology · 2026
    Review
  16. Review
  17. Article
  18. The gut-joint axis in osteoarthritis.Nature reviews. Rheumatology · 2026
    Review
  19. Article
  20. Review

252 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Catalin ChimerelInstitute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK. Electronic address: cc539@cam.ac.uk.
Edward EmeryInstitute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
David K SummersDepartment of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Ulrich KeyserCavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE, UK.
Fiona M GribbleInstitute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: fmg23@cam.ac.uk.
Frank ReimannInstitute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: fr222@cam.ac.uk.
Addenbrooke's Hospital · GBUniversity of Cambridge · GB

Funding

European Research Council 261101Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Wellcome Trust 084210Wellcome Trust 088357Wellcome Trust WT084210/Z/07/ZWellcome Trust WT088357/Z/09/Z
6 · The paper itself

Abstract

It has long been speculated that metabolites, produced by gut microbiota, influence host metabolism in health and diseases. Here, we reveal that indole, a metabolite produced from the dissimilation of tryptophan, is able to modulate the secretion of glucagon-like peptide-1 (GLP-1) from immortalized and primary mouse colonic L cells. Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods. These effects were attributed to the ability of indole to affect two key molecular mechanisms in L cells. On the one hand, indole inhibited voltage-gated K(+) channels, increased the temporal width of action potentials fired by L cells, and led to enhanced Ca(2+) entry, thereby acutely stimulating GLP-1 secretion. On the other hand, indole slowed ATP production by blocking NADH dehydrogenase, thus leading to a prolonged reduction of GLP-1 secretion. Our results identify indole as a signaling molecule by which gut microbiota communicate with L cells and influence host metabolism.

Indexed as

Action PotentialsAdenosine DiphosphateAdenosine TriphosphateAnimalsCalciumCells, CulturedColonEnteroendocrine CellsGlucagon-Like Peptide 1IncretinsIndolesIonsMiceNADPPotassium Channels, Voltage-GatedPotassium ChlorideAdenosine DiphosphateAdenosine TriphosphateCalciumGlucagon-Like Peptide 1IncretinsindoleIndolesIonsNADPPotassium Channels, Voltage-GatedPotassium Chloride

Identifiers

PMID25456122
PMCPMC4308618
OpenAlexW2042394891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.