ReviewFrontiers in neuroendocrinology2015
Photoperiodic time measurement and seasonal immunological plasticity.
Review in Frontiers in neuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Low-Dose Vitamin DFrontiers in immunology · 2021Trial
- Endocrine and molecular regulation of seasonal avian immune function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Seasonal variation in sunlight exposure is differently associated with changes in T regulatory and T-helper 17 cell blood counts in adolescent and adults females: a pilot study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Annual rhythm in immune functions of blood leucocytes in an ophidian, Natrix piscator.Scientific reports · 2024Article
- Photoperiod Conditions Modulate Serum Oxylipins Levels in Healthy and Obese Rats: Impact of Proanthocyanidins and Gut Microbiota.Nutrients · 2023Article
- Fitness consequences of chronic exposure to different light pollution wavelengths in nocturnal and diurnal rodents.Scientific reports · 2022Article
- Article
- Effects of light pollution on photoperiod-driven seasonality.Hormones and behavior · 2022Review
- Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort.iScience · 2021Article
- Drivers of Infectious Disease Seasonality: Potential Implications for COVID-19.Journal of biological rhythms · 2021Review
- Prior exposure to long-day photoperiods alters immune responses and increases susceptibility to parasitic infection in stickleback.Proceedings. Biological sciences · 2020Article
- Season and sex have different effects on hematology and cytokines in striped hamsters (Cricetulus barabensis).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- Photoperiodic Effects on Diurnal Rhythms in Cell Numbers of Peripheral Leukocytes in Domestic Pigs.Frontiers in immunology · 2019Article
- Article
- A genetics-based approach confirms immune associations with life history across multiple populations of an aquatic vertebrate (Gasterosteus aculeatus).Molecular ecology · 2018Article
- Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle.Endocrinology · 2018Article
- The Value of Comparative Animal Research: Krogh's Principle Facilitates Scientific Discoveries.Policy insights from the behavioral and brain sciences · 2018Article
- Biological Clocks and Rhythms of Anger and Aggression.Frontiers in behavioral neuroscience · 2018Review
- Physical Cues Controlling Seasonal Immune Allocation in a Natural Piscine Model.Frontiers in immunology · 2018Article
- A time for everything and everything in its time - exploring the mechanisms underlying seasonality of COPD exacerbations.International journal of chronic obstructive pulmonary disease · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Seasonal variations in immunity are common in nature, and changes in day length are sufficient to trigger enhancement and suppression of immune function in many vertebrates. Drawing primarily on data from Siberian hamsters, this review describes formal and physiological aspects of the neuroendocrine regulation of seasonal changes in mammalian immunity. Photoperiod regulates immunity in a trait-specific manner, and seasonal changes in gonadal hormone secretion and thyroid hormone signaling all participate in seasonal immunomodulation. Photoperiod-driven changes in the hamster reproductive and immune systems are associated with changes in iodothyronine deiodinase-mediated thyroid hormone signaling, but photoperiod exerts opposite effects on select aspects of the epigenetic regulation of reproductive neuroendocrine and lymphoid tissues. Photoperiodic changes in immunocompetence may explain a proportion of the annual variance in disease incidence and severity in nature, and provide a useful framework to help understand brain-immune interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.