ArticleChemistry & biology2014
Quorum-sensing crosstalk-driven synthetic circuits: from unimodality to trimodality.
Article in Chemistry & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- γ-Butyrolactones and γ-butenolides as autoregulatory systems: key mediators of intraspecific, interspecific, and interkingdom communication in Streptomyces.Archives of microbiology · 2026Review
- Extracellular vesicles as structured vectors of quorum sensing signals influence aquatic microbial communities.NPJ biofilms and microbiomes · 2026Article
- From single cells to communities: Mathematical perspectives on bacterial quorum sensing.Computational and structural biotechnology journal · 2025Review
- DyMMM-LEAPS: An ML-based framework for modulating evenness and stability in synthetic microbial communities.Biophysical journal · 2024Article
- What can we learn when fitting a simple telegraph model to a complex gene expression model?PLoS computational biology · 2024Article
- Synthetic Homoserine Lactone Sensors for Gram-PositiveACS synthetic biology · 2024Article
- Crosstalk enables mutual activation of coupled quorum sensing pathways through "jump-start" and "push-start" mechanisms.Scientific reports · 2023Article
- Redesigning regulatory components of quorum-sensing system for diverse metabolic control.Nature communications · 2022Article
- Characterizing chemical signaling between engineered "microbial sentinels" in porous microplates.Molecular systems biology · 2022Article
- Engineered microbial consortia: strategies and applications.Microbial cell factories · 2021Review
- A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules.Science China. Life sciences · 2021Article
- Design patterns for engineering genetic stability.Current opinion in biomedical engineering · 2021Article
- Predictable control of RNA lifetime using engineered degradation-tuning RNAs.Nature chemical biology · 2021Article
- Predictive biology: modelling, understanding and harnessing microbial complexity.Nature reviews. Microbiology · 2020Review
- Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling.PLoS computational biology · 2020Article
- Topology-dependent interference of synthetic gene circuit function by growth feedback.Nature chemical biology · 2020Article
- Evolutionary regain of lost gene circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Digitalizing heterologous gene expression in Gram-negative bacteria with a portable ON/OFF module.Molecular systems biology · 2019Article
- Gene networks that compensate for crosstalk with crosstalk.Nature communications · 2019Article
- A neural network model predicts community-level signaling states in a diverse microbial community.PLoS computational biology · 2019Article
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Abstract
Widespread quorum-sensing (QS) enables bacteria to communicate and plays a critical role in controlling bacterial virulence. However, effects of promiscuous QS crosstalk and its implications for gene regulation and cell decision-making remain largely unknown. Here we systematically studied the crosstalk between LuxR/I and LasR/I systems and found that QS crosstalk can be dissected into signal crosstalk and promoter crosstalk. Further investigations using synthetic positive feedback circuits revealed that signal crosstalk significantly decreases a circuit's bistable potential while maintaining unimodality. Promoter crosstalk, however, reproducibly generates complex trimodal responses resulting from noise-induced state transitions and host-circuit interactions. A mathematical model that integrates the circuit's nonlinearity, stochasticity, and host-circuit interactions was developed, and its predictions of conditions for trimodality were verified experimentally. Combining synthetic biology and mathematical modeling, this work sheds light on the complex behaviors emerging from QS crosstalk, which could be exploited for therapeutics and biotechnology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.