Evidence map›Paper›PMID 25455735›Full record

ArticleJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2015

Supratentorial extraventricular anaplastic ependymoma with extracranial metastasis.

Laura A Pachella, Carlos Kamiya-Matsuoka, Eva Lu T Lee, Adriana Olar, W K Alfred Yung

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Metastatic Supratentorial Ependymoma: A Case Presentation and Systematic Review of the Literature.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laura A PachellaDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Boulevard, Room FC7.3000, Unit 431, Houston, TX 77030, USA. Electronic address: lpachella@mdanderson.org.
Carlos Kamiya-MatsuokaDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Boulevard, Room FC7.3000, Unit 431, Houston, TX 77030, USA.
Eva Lu T LeeDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Boulevard, Room FC7.3000, Unit 431, Houston, TX 77030, USA.
Adriana OlarDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
W K Alfred YungDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Boulevard, Room FC7.3000, Unit 431, Houston, TX 77030, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Multidisciplinary Subspecialty Pathology Research Fellowship ProgramT32CA163185 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CZERNIAK, BOGDAN A, KEYOMARSI, KHANDAN · 2011 to 2015
$1.7M
NCI NIH HHS 5T32CA163185NCI NIH HHS T32 CA163185
6 · The paper itself

Abstract

Ependymoma is a relatively rare malignancy accounting for 2.0% of all primary central nervous system tumors in adults. Extracranial metastasis is a very uncommon complication of gliomas, especially of anaplastic ependymomas. The objective of this paper is to show that ependymomas can metastasize to soft tissue and lymph nodes as well as to share our approach to this challenge. We report a male patient with anaplastic ependymoma that recurred, metastasizing to the neck and lymph nodes. Metastatic disease was diagnosed based on clinical presentation of a palpable nodule on the right neck and diffuse cervical lymphadenopathies. A biopsy was obtained and pathology revealed anaplastic ependymoma. Whole-body fluorodeoxyglucose positron emission tomography scan showed metastatic disease in the right mastoid region with diffuse uptake in the cervical lymph nodes. Clinical and radiologic response was achieved after three chemotherapy cycles of etoposide, cisplatin, vincristine, and cyclophosphamide. This case highlights extracranial metastasis to the soft tissue as an atypical presentation of recurrent anaplastic ependymoma. Other reported instances of extracranial metastatic ependymoma with this presentation are discussed. The possible metastatic pathways of intracranial disease are discussed. It also illustrates how extracranial disease remains stable with systemic chemotherapy.

Indexed as

Brain NeoplasmsEpendymomaHumansLymphatic MetastasisMaleNeckSoft Tissue NeoplasmsYoung AdultAnaplastic ependymomaExtracranial metastasesExtraneural metastases

Identifiers

PMID25455735
PMCPMC4385743
OpenAlexW2041975595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.