Evidence map›Paper›PMID 25455510›Full record

SynthesisJournal of psychiatric research2015

A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor.

Kristin L Szuhany, Matteo Bugatti, Michael W Otto

3 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 437 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
437citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04254146 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effects of Acute Exercise on BDNF Levels in Rheumatoid Arthritis Patients

TypeinterventionalSponsorGazi UniversityRan2020 to 2020Enrolled60ConditionsRheumatoid ArthritisArmsAerobic exercise
NCT04439682 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis

TypeinterventionalSponsorGazi UniversityRan2020 to 2021Enrolled90ConditionsRheumatoid ArthritisArmsAerobic exercise
NCT06213883 nacompletednot on this mapstarted 2023, after this paper: background citation

Characterizing Acute Exercise Response in Restrictive Eating Disorders

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2023 to 2025Enrolled74ConditionsEating DisordersArmsBiobehavioral Response to in-lab exposure to physical activity
3 · Its place in the literature

Who cites it

437 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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377 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristin L SzuhanyDepartment of Psychological and Brain Sciences, Boston University, 648 Beacon St., 5th Floor, Boston, MA 02215, USA. Electronic address: kszuhany@bu.edu.
Matteo BugattiDepartment of Psychological and Brain Sciences, Boston University, 648 Beacon St., 5th Floor, Boston, MA 02215, USA.
Michael W OttoDepartment of Psychological and Brain Sciences, Boston University, 648 Beacon St., 5th Floor, Boston, MA 02215, USA.

Funding

Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major DepressionF31MH100773 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SZUHANY, KRISTIN L. · 2013 to 2016
$93k
NIMH NIH HHS F31 MH100773
6 · The paper itself

Abstract

Consistent evidence indicates that exercise improves cognition and mood, with preliminary evidence suggesting that brain-derived neurotrophic factor (BDNF) may mediate these effects. The aim of the current meta-analysis was to provide an estimate of the strength of the association between exercise and increased BDNF levels in humans across multiple exercise paradigms. We conducted a meta-analysis of 29 studies (N = 1111 participants) examining the effect of exercise on BDNF levels in three exercise paradigms: (1) a single session of exercise, (2) a session of exercise following a program of regular exercise, and (3) resting BDNF levels following a program of regular exercise. Moderators of this effect were also examined. Results demonstrated a moderate effect size for increases in BDNF following a single session of exercise (Hedges' g = 0.46, p < 0.001). Further, regular exercise intensified the effect of a session of exercise on BDNF levels (Hedges' g = 0.59, p = 0.02). Finally, results indicated a small effect of regular exercise on resting BDNF levels (Hedges' g = 0.27, p = 0.005). When analyzing results across paradigms, sex significantly moderated the effect of exercise on BDNF levels, such that studies with more women showed less BDNF change resulting from exercise. Effect size analysis supports the role of exercise as a strategy for enhancing BDNF activity in humans, but indicates that the magnitude of these effects may be lower in females relative to males.

Indexed as

AdultAge FactorsBrain-Derived Neurotrophic FactorExerciseFemaleHumansMaleMotor ActivitySex FactorsTime FactorsBrain-Derived Neurotrophic FactorBDNFBrain-derived neurotrophic factorExerciseMeta-analysisPhysical activity

Identifiers

PMID25455510
PMCPMC4314337

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.