Trial reportAmerican journal of preventive medicine2014
Effect of decision support on missed opportunities for human papillomavirus vaccination.
Trial report in American journal of preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Health Information Technology to Improve Healthcare Quality in Primary Care Practices and in Transitions Between Care Settings
HPV Vaccination: Evaluation of Reminder Prompts for Doses 2 & 3
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Audit and feedback: effects on professional practice.The Cochrane database of systematic reviews · 2025Pooled it
- A systematic review and meta-analysis of strategies to promote vaccination uptake.Nature human behaviour · 2024Pooled it
- What maximizes the effectiveness and implementation of technology-based interventions to support healthcare professional practice? A systematic literature review.BMC medical informatics and decision making · 2018Pooled it
- The effects of on-screen, point of care computer reminders on processes and outcomes of care.The Cochrane database of systematic reviews · 2009Pooled it
- Effect of Electronic Health Record Reminders for Routine Immunizations and Immunizations Needed for Chronic Medical Conditions.Applied clinical informatics · 2021Trial
- Clinical Decision Support for Recognizing and Managing Hypertensive Blood Pressure in Youth: No Significant Impact on Medical Costs.Academic pediatrics · 2020Trial
- Evaluating the impact of multilevel evidence-based implementation strategies to enhance provider recommendation on human papillomavirus vaccination rates among an empaneled primary care patient population: a study protocol for a stepped-wedge cluster randomized trial.Implementation science : IS · 2018Trial
- Trial
- Promoting HPV Vaccination in Safety-Net Clinics: A Randomized Trial.Pediatrics · 2015Trial
- Trial
- Clinician Prompts for Human Papillomavirus Vaccination: A Cluster Randomized Trial.Academic pediatricsTrial
- Health Equity and Human Papillomavirus Vaccine Interventions for Adolescents: A Systematic Review.Vaccines · 2025Review
- Review
- A Bundled, Practice-Based Intervention to Increase HPV Vaccination.Pediatrics · 2025Article
- Article
- Measurement of provider fidelity to immunization guidelines: a mixed-methods study on the feasibility of documenting patient refusals of the human papillomavirus vaccine.BMC medical informatics and decision making · 2022Observational
- Healthcare providers' practice protocols, strategies, and needed tools to address parental HPV vaccine hesitancy: An exploratory study.Human vaccines & immunotherapeutics · 2022Article
- Article
- Added Value of Electronic Immunization Registries in Low- and Middle-Income Countries: Observational Case Study in Tanzania.JMIR public health and surveillance · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMissed opportunities for human papilloma virus (HPV) vaccination are common, presenting a barrier to achieving widespread vaccine coverage and preventing infection. PURPOSE: To compare the impact of clinician- versus family-focused decision support, none, or both on captured opportunities for HPV vaccination.
designTwelve-month cluster randomized controlled trial conducted in 2010-2011. SETTING/
participantsAdolescent girls aged 11-17 years due for HPV Dose 1, 2, or 3 receiving care at primary care practices.
interventionTwenty-two primary care practices were cluster randomized to receive a three-part clinician-focused intervention (educational sessions, electronic health record-based alerts, and performance feedback) or none. Within each practice, girls were randomized at the patient level to receive family-focused, automated, educational phone calls or none. Randomization resulted in four groups: clinician-focused, family-focused, combined, or no intervention.
main outcome measuresStandardized proportions of captured opportunities (due vaccine received at clinician visit) were calculated among girls in each study arm. Analyses were conducted in 2013.
resultsAmong 17,016 adolescent girls and their 32,472 visits (14,247 preventive, 18,225 acute), more HPV opportunities were captured at preventive than acute visits (36% vs 4%, p<0.001). At preventive visits, the clinician intervention increased captured opportunities by 9 percentage points for HPV-1 and 6 percentage points for HPV-3 (p≤0.01), but not HPV-2. At acute visits, the clinician and combined interventions significantly improved captured opportunities for all three doses (p≤0.01). The family intervention was similar to none. Results differed by practice setting; at preventive visits, the clinician intervention was more effective for HPV-1 in suburban than urban settings, whereas at acute visits, the clinician intervention was more effective for all doses at urban practices.
conclusionsClinician-focused decision support is a more effective strategy than family-focused to prevent missed HPV vaccination opportunities. Given the persistence of missed opportunities even in intervention groups, complementary strategies are needed. This study is registered at clinicaltrials.gov NCT01159093.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.