ReviewSchizophrenia research2015
Consortium on the Genetics of Schizophrenia (COGS) assessment of endophenotypes for schizophrenia: an introduction to this Special Issue of Schizophrenia Research.
Review in Schizophrenia research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Model-Based Electroencephalography Phenotyping Uncovers Distinct Neurocomputational Mechanisms Underlying Learning Impairments Across Psychopathologies.Biological psychiatry global open science · 2026Article
- Clarifying directional dependence among measures of early auditory processing and cognition in schizophrenia: leveraging Gaussian graphical models and Bayesian networks.Psychological medicine · 2024Article
- Extent to which array genotyping and imputation with large reference panels approximate deep whole-genome sequencing.American journal of human genetics · 2022Article
- Comparative Analysis of Dopaminergic and Cholinergic Mechanisms of Sensory and Sensorimotor Gating in Healthy Individuals and in Patients With Schizophrenia.Frontiers in behavioral neuroscience · 2022Review
- Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.The American journal of psychiatry · 2021Article
- A novel construct of anhedonia revealed in a Chinese sample via the Revised Physical and Social Anhedonia Scales.BMC psychiatry · 2020Article
- Article
- Decomposing the constituent oscillatory dynamics underlying mismatch negativity generation in schizophrenia: Distinct relationships to clinical and cognitive functioning.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Article
- NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis.Translational psychiatry · 2019Article
- Exploring neurologists' perspectives on the return of next generation sequencing results to their patients: a needed step in the development of guidelines.BMC medical ethics · 2018Article
- Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension.Schizophrenia research · 2018Article
- Dimensional Traits of Schizotypy Associated With Glycine Receptor GLRA1 Polymorphism: An Exploratory Candidate-Gene Association Study.Journal of personality disorders · 2018Article
- Neurological soft signs precede the onset of schizophrenia: a study of individuals with schizotypy, ultra-high-risk individuals, and first-onset schizophrenia.European archives of psychiatry and clinical neuroscience · 2018Article
- Genetic tests in major psychiatric disorders-integrating molecular medicine with clinical psychiatry-why is it so difficult?Translational psychiatry · 2017Review
- Practices and views of neurologists regarding the use of whole-genome sequencing in clinical settings: a web-based survey.European journal of human genetics : EJHG · 2017Article
- A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway.Brain sciences · 2017Review
- Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia.JAMA psychiatry · 2017Article
- Endophenotypes, Epigenetics, Polygenicity and More: Irv Gottesman's Dynamic Legacy.Schizophrenia bulletin · 2017Review
- Endophenotype best practices.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Review
- Prioritizing schizophrenia endophenotypes for future genetic studies: An example using data from the COGS-1 family study.Schizophrenia research · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe COGS is a multi-site NIMH-sponsored investigation of the genetic basis of 12 primary and multiple secondary quantitative endophenotypes in schizophrenia.
methodsSince 2003, COGS has completed studies using a family-based ascertainment strategy (COGS-1), and a case-control ascertainment strategy (COGS-2) (cumulative "n">4000).
resultsCOGS-1 family study confirmed robust deficits in, and heritability of, these endophenotypes in schizophrenia, and provided evidence for a coherent genetic architecture underlying the risk for neurocognitive and neurophysiological deficits in this disorder. COGS-2 case-control findings, many reported herein, establish a foundation for fine genomic mapping and other analyses of these endophenotypes and risk genes for SZ. Several reports in this Special Issue compare findings of endophenotype deficits generated by fundamentally different COGS-1 vs. COGS-2 ascertainment strategies. Despite the expectation that family-based and case-control designs would establish demographically and potentially biologically distinct patient cohorts, findings generally revealed comparable patterns of endophenotype deficits across studies. The COGS-2 case-control design facilitated the accrual of a larger "n", permitting detailed analyses of factors moderating endophenotype performance. Some COGS-2 endophenotypes not assessed in COGS-1 are also reported, as is a new factor analytic strategy for identifying shared vs. unique factors among the COGS endophenotypes which can be used to develop composite variables with distinct genetic signatures. DISCUSSION: The path to date of COGS-1 endophenotype and genetic findings, followed by replication and extension in COGS-2, establishes benchmarks for endophenotype deficits in SZ and their moderation by specific factors, and clear expectations for informative findings from upcoming COGS-2 genetic analyses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.