ArticleStem cell reports2014
Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain.Cell reports · 2024Article
- RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1.Cellular and molecular life sciences : CMLS · 2024Article
- Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease.Cell death & disease · 2023Article
- Article
- Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application.Frontiers in cell and developmental biology · 2021Review
- Five transcriptional factors reprogram fibroblast into myogenic lineage cells via paraxial mesoderm stage.Cell cycle (Georgetown, Tex.) · 2020Article
- The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.Scientific reports · 2018Article
- Activation of podocyte Notch mediates early Wt1 glomerulopathy.Kidney international · 2018Article
- Adult Neural Stem Cells: Basic Research and Production Strategies for Neurorestorative Therapy.Stem cells international · 2018Review
- Current progress in the derivation and therapeutic application of neural stem cells.Cell death & disease · 2017Review
- Induced dopaminergic neurons: A new promise for Parkinson's disease.Redox biology · 2017Article
- New approaches for direct conversion of patient fibroblasts into neural cells.Brain research · 2017Review
- Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.NPJ breast cancer · 2017Article
- Grafted Subventricular Zone Neural Stem Cells Display Robust Engraftment and Similar Differentiation Properties and Form New Neurogenic Niches in the Young and Aged Hippocampus.Stem cells translational medicine · 2016Article
- Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes.Cell reports · 2016Article
- Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience.Nature reviews. Neuroscience · 2016Review
- Generation of Integration-free Induced Neural Stem Cells from Mouse Fibroblasts.The Journal of biological chemistry · 2016Article
- Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.Cell stem cell · 2016Article
- Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor.Stem cell reports · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Overexpression of transcription factors has been used to directly reprogram somatic cells into a range of other differentiated cell types, including multipotent neural stem cells (NSCs), that can be used to generate neurons and glia. However, the ability to maintain the NSC state independent of the inducing factors and the identity of the somatic donor cells remain two important unresolved issues in transdifferentiation. Here we used transduction of doxycycline-inducible transcription factors to generate stable tripotent NSCs. The induced NSCs (iNSCs) maintained their characteristics in the absence of exogenous factor expression and were transcriptionally, epigenetically, and functionally similar to primary brain-derived NSCs. Importantly, we also generated tripotent iNSCs from multiple adult cell types, including mature liver and B cells. Our results show that self-maintaining proliferative neural cells can be induced from nonectodermal cells by expressing specific combinations of transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.