Evidence map›Paper›PMID 25454591›Full record

ArticleCurrent biology : CB2014

CREB regulates memory allocation in the insular cortex.

Yoshitake Sano, Justin L Shobe, Miou Zhou, Shan Huang, Tristan Shuman, Denise J Cai, Peyman Golshani, Masakazu Kamata, Alcino J Silva

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 101 citations in OpenAlex.

  1. Review
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  5. A neural mechanism for learning from delayed postingestive feedback.bioRxiv : the preprint server for biology · 2024
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  7. Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. The intricate role of CCL5/CCR5 axis in Alzheimer disease.Journal of neuropathology and experimental neurology · 2023
    Review
  12. Review
  13. Formation and fate of an engram in the lateral amygdala supporting a rewarding memory in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  14. Article
  15. Opto-extinction of a threat memory in mice.Brain research bulletin · 2022
    Article
  16. PDE2A Inhibition Enhances Axonal Sprouting, Functional Connectivity, and Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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  20. Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yoshitake SanoDepartments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Justin L ShobeDepartments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Miou ZhouDepartments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Shan HuangDepartments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tristan ShumanDepartment of Neurology at David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Denise J CaiDepartments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Peyman GolshaniDepartment of Neurology at David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Masakazu KamataDepartment of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Alcino J SilvaDepartments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: silvaa@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Gene Targeting Approaches to Learning and Memory StudiesR37AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2007 to 2016
$5.4M
Molecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingRF1AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2022
$4.9M
Molecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingR01AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani · 1995 to 2026
$3.3M
Gene Targeting Approaches to Learning and Memory StudiesU01AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TRACHTENBERG, JOSHUA · 2005 to 2006
$976k
NIA NIH HHS R01 AG013622NIA NIH HHS R37 AG013622NIA NIH HHS RF1 AG013622NIA NIH HHS U01 AG013622
6 · The paper itself

Abstract

The molecular and cellular mechanisms of memory storage have attracted a great deal of attention. By comparison, little is known about memory allocation, the process that determines which specific neurons in a neural network will store a given memory. Previous studies demonstrated that memory allocation is not random in the amygdala; these studies showed that amygdala neurons with higher levels of the cyclic-AMP-response-element-binding protein (CREB) are more likely to be recruited into encoding and storing fear memory. To determine whether specific mechanisms also regulate memory allocation in other brain regions and whether CREB also has a role in this process, we studied insular cortical memory representations for conditioned taste aversion (CTA). In this task, an animal learns to associate a taste (conditioned stimulus [CS]) with the experience of malaise (such as that induced by LiCl; unconditioned stimulus [US]). The insular cortex is required for CTA memory formation and retrieval. CTA learning activates a subpopulation of neurons in this structure, and the insular cortex and the basolateral amygdala (BLA) interact during CTA formation. Here, we used a combination of approaches, including viral vector transfections of insular cortex, arc fluorescence in situ hybridization (FISH), and designer receptors exclusively activated by designer drugs (DREADD) system, to show that CREB levels determine which insular cortical neurons go on to encode a given conditioned taste memory.

Indexed as

AnimalsAvoidance LearningCerebral CortexConditioning, ClassicalCyclic AMP Response Element-Binding ProteinGene SilencingHumansIn Situ Hybridization, FluorescenceLithium ChlorideMemoryMice, Inbred C57BLNeuronsTasteCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinLithium Chloride

Identifiers

PMID25454591
PMCPMC4743759
OpenAlexW2084834612

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.