ArticleDevelopmental cognitive neuroscience2015
The effects of puberty on white matter development in boys.
Article in Developmental cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A systematic review of adrenarche as a sensitive period in neurobiological development and mental health.Developmental cognitive neuroscience · 2017Pooled it
- Machine Learning-Powered fNIRS Detection of Idiopathic Central Precocious Puberty via Prefrontal Cortex Activation.BME frontiers · 2026Article
- Sex differences in maturational timing of amygdala and prefrontal cortex volumes and white matter tract microstructure.Developmental cognitive neuroscience · 2025Article
- Diffusion indices alteration in major white matter tracts of children with tic disorder using TRACULA.Journal of neurodevelopmental disorders · 2024Article
- The Role of Puberty and Sex on Brain Structure in Adolescents With Anxiety Following Concussion.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- White matter microstructure in transmasculine and cisgender adolescents: A multiparametric and multivariate study.PloS one · 2024Article
- Developmental changes in endogenous testosterone have sexually-dimorphic effects on spontaneous cortical dynamics.Human brain mapping · 2023Article
- Puberty differentially predicts brain maturation in male and female youth: A longitudinal ABCD Study.Developmental cognitive neuroscience · 2023Article
- Does pubertal stage mediate the association between family environment and structure and function of the amygdala-mPFC circuit? A replication study of the longitudinal ABCD cohort.Developmental cognitive neuroscience · 2022Article
- The Structural Connectome and Internalizing and Externalizing Symptoms at 7 and 13 Years in Individuals Born Very Preterm and Full Term.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: a consideration of the role of puberty.Molecular psychiatry · 2022Review
- Exploring valence bias as a metric for frontoamygdalar connectivity and depressive symptoms in childhood.Developmental psychobiology · 2021Article
- Calendar age and puberty-related development of regional gray matter volume and white matter tracts during adolescence.Brain structure & function · 2021Article
- Sex hormones partially explain the sex-dependent effect of lifetime alcohol use on adolescent white matter microstructure.Psychiatry research. Neuroimaging · 2021Article
- Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health.Frontiers in aging neuroscience · 2021Article
- Longitudinal patterns of white matter fibre density and morphology in children are associated with age and pubertal stage.Developmental cognitive neuroscience · 2020Article
- Sex differences in the effects of gonadal hormones on white matter microstructure development in adolescence.Developmental cognitive neuroscience · 2020Article
- Neurocognitive reorganization between crystallized intelligence, fluid intelligence and white matter microstructure in two age-heterogeneous developmental cohorts.Developmental cognitive neuroscience · 2020Article
- A multiparametric analysis of white matter maturation during late childhood and adolescence.Human brain mapping · 2019Article
- Mapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neuroimaging studies demonstrate considerable changes in white matter volume and microstructure during adolescence. Most studies have focused on age-related effects, whilst puberty-related changes are not well understood. Using diffusion tensor imaging and tract-based spatial statistics, we investigated the effects of pubertal status on white matter mean diffusivity (MD) and fractional anisotropy (FA) in 61 males aged 12.7-16.0 years. Participants were grouped into early-mid puberty (≤Tanner Stage 3 in pubic hair and gonadal development; n=22) and late-post puberty (≥Tanner Stage 4 in pubic hair or gonadal development; n=39). Salivary levels of pubertal hormones (testosterone, DHEA and oestradiol) were also measured. Pubertal stage was significantly related to MD in diverse white matter regions. No relationship was observed between pubertal status and FA. Regression modelling of MD in the significant regions demonstrated that an interaction model incorporating puberty, age and puberty×age best explained our findings. In addition, testosterone was correlated with MD in these pubertally significant regions. No relationship was observed between oestradiol or DHEA and MD. In conclusion, pubertal status was significantly related to MD, but not FA, and this relationship cannot be explained by changes in chronological age alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.