Evidence map›Paper›PMID 25454409›Full record

Trial reportDrug and alcohol dependence2014

Assessing craving and its relationship to subsequent prescription opioid use among treatment-seeking prescription opioid dependent patients.

R Kathryn McHugh, Garrett M Fitzmaurice, Kathleen M Carroll, Margaret L Griffin, Kevin P Hill, Ajay D Wasan, Roger D Weiss

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05047627 (Digital Intervention to Treat Anxiety and Depression Among Persons Receiving Treatment for Opioid Use Disorder), which is not on this map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05047627 nacompletednot on this mapstarted 2021, after this paper: background citation

Digital Intervention to Treat Anxiety and Depression Among Persons Receiving Treatment for Opioid Use Disorder

TypeinterventionalSponsorTrustees of Dartmouth CollegeRan2021 to 2023Enrolled63ConditionsOpioid-use Disorder, Anxiety Disorders, Depressive DisorderArmsSmartphone-Based Digital Intervention
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. A Systematic Review of Noninvasive Brain Stimulation for Opioid Use Disorder.Neuromodulation : journal of the International Neuromodulation Society · 2020
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Developing a novel treatment for patients with chronic pain and Opioid User Disorder.Substance abuse treatment, prevention, and policy · 2022
    Trial
  11. Trial
  12. Bupropion and Naltrexone in Methamphetamine Use Disorder.The New England journal of medicine · 2021
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Article
  18. Article
  19. Observational
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

R Kathryn McHughDivision of Alcohol and Drug Abuse, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: kmchugh@mclean.harvard.edu.
Garrett M FitzmauriceDepartment of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Laboratory for Psychiatric Biostatistics, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
Kathleen M CarrollDepartment of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, MIRECC 151D, West Haven, CT 06516, USA.
Margaret L GriffinDivision of Alcohol and Drug Abuse, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Kevin P HillDivision of Alcohol and Drug Abuse, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Ajay D WasanDepartments of Anesthesiology and Psychiatry, University of Pittsburgh School of Medicine, 5750 Centre Avenue, Suite 400, Pittsburgh, PA 15206, USA.
Roger D WeissDivision of Alcohol and Drug Abuse, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
McLean Hospital · USHarvard University · USUniversity of Pittsburgh · US

Funding

The National Drug Abuse Treatment Clinical Trials Network (U10)U10DA015831 · NIDA · MC LEAN HOSPITAL (BELMONT, MA) · PI CARROLL, KATHLEEN M., WEISS, ROGER D. · 2002 to 2015
$28.8M
Mentoring in Drug Abuse and Dual Diagnosis ResearchK24DA022288 · NIDA · MCLEAN HOSPITAL · PI WEISS, ROGER D. · 2007 to 2016
$1.8M
GENDER DIFFERENCES IN MECHANISMS OF RECOVERY FROM OPIOID USE DISORDER AND ANXIETYK23DA035297 · NIDA · MCLEAN HOSPITAL · PI MCHUGH, REBECCA KATHRYN · 2014 to 2018
$959k
Nabilone for Cannabis Dependence: Imaging and Neuropsychological PerformanceR00DA029115 · NIDA · MCLEAN HOSPITAL · PI HILL, KEVIN P. · 2013 to 2015
$819k
NIDA NIH HHS K23 DA035297NIDA NIH HHS K24 DA022288NIDA NIH HHS K99R00 DA029115NIDA NIH HHS R00 DA029115NIDA NIH HHS U10 DA015831
6 · The paper itself

Abstract

backgroundCraving is viewed as a core feature of substance use disorders and has been shown to predict future drug use, particularly over the short term. Accordingly, craving is often assessed in treatment settings as a marker of risk for subsequent drug use. The identification of the briefest measure that maintains predictive validity is of particular value for both clinical and research settings to minimize assessment burden while maintaining utility for the prediction of use.

methodsData from a multi-site clinical trial of treatment for prescription opioid dependence were examined to evaluate whether a brief, 3-item craving scale administered each week predicted urine-confirmed self report of prescription opioid use in the subsequent week. Logistic regression models examining the association between craving and presence or absence of opioid use in the following week were conducted, controlling for opioid use in the previous week, treatment condition, and lifetime history of heroin use.

resultsGreater craving was associated with a higher odds of prescription opioid use in the following week. For each one-unit increase on this 10-point scale, the odds of using opioids in the subsequent week was 17% higher. In addition to an item assessing urges, items assessing cue-induced craving and perceived likelihood of relapse in an environment where drugs were previously used contributed uniquely to this association.

conclusionsA brief measure of prescription opioid craving predicted prescription opioid use among individuals in treatment. This measure offers an efficient strategy to inform the assessment of risk for use in this population.

Indexed as

CravingDrug PrescriptionsSubstance Abuse Treatment CentersAdultAnalgesics, OpioidFemaleHeroinHumansMaleNarcotic AntagonistsOpioid-Related DisordersSelf ReportYoung AdultAnalgesics, OpioidHeroinNarcotic AntagonistsBuprenorphineCravingCue-induced cravingPrescription opioids

Identifiers

PMID25454409
PMCPMC4254575
OpenAlexW1967066293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.