ArticleThe Journal of pediatrics2015
Serum D-dimer concentrations are increased after pediatric traumatic brain injury.
Article in The Journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Skull fractures may be associated with hyperfibrinolysis in patients with isolated traumatic brain injury.Clinical and experimental emergency medicine · 2026Article
- C-Reactive Protein and D-dimer as Prognostic Markers for Clinical Outcomes in Patients with Mild Traumatic Brain Injury: A Cross-Sectional Study.Bulletin of emergency and trauma · 2023Article
- Plasma D-dimer levels are a biomarker for in-hospital complications and long-term mortality in patients with traumatic brain injury.Frontiers in molecular neuroscience · 2023Article
- BIG score is a strong predictor of mortality and morbidity for high-energy traumas in pediatric intensive care unit.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Article
- An update on diagnostic and prognostic biomarkers for traumatic brain injury.Expert review of molecular diagnostics · 2018Review
- Translating biomarkers from research to clinical use in pediatric neurocritical care: focus on traumatic brain injury and cardiac arrest.Current opinion in pediatrics · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo determine whether D-dimer would be increased in children with traumatic brain injury (TBI), specifically mild abusive head trauma. STUDY
designD-dimer was measured using multiplex bead technology in 195 children <4 years old (n = 93 controls without TBI, n = 102 cases with TBI) using previously collected serum. D-dimer was then measured prospectively in a clinical setting in 44 children (n = 24 controls, n = 20 cases). Receiver operator curves were generated for prospective data.
resultsIn both the retrospective and prospective cohorts, median (25th-75th percentile) D-dimer was significantly higher in cases vs controls. A receiver operator curve demonstrated an area under the curve of 0.91 (95% CI 0.83-0.99) in the prospective cohort. At a cut-off of 0.59 μg/L, the sensitivity and specificity for identification of a case was 90% and 75%, respectively.
conclusionsOur data suggest that serum D-dimer may be able to be used to identify which young children at risk for abusive head trauma might benefit from a head computed tomography or other additional evaluation. Additional data are needed to better identify the clinical scenarios that may result in false positive or false negative D-dimer concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.