ReviewTrends in cardiovascular medicine2015
"Beauty is a light in the heart": the transformative potential of optogenetics for clinical applications in cardiovascular medicine.
Review in Trends in cardiovascular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Protein design accelerates the development and application of optogenetic tools.Computational and structural biotechnology journal · 2025Review
- A micro-LED array based platform for spatio-temporal optogenetic control of various cardiac models.Scientific reports · 2023Article
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021Review
- Neurohumoral Cardiac Regulation: Optogenetics Gets Into the Groove.Frontiers in physiology · 2021Review
- Optogenetic Stimulation Using Anion Channelrhodopsin (GtACR1) Facilitates Termination of Reentrant Arrhythmias With Low Light Energy Requirements: A Computational Study.Frontiers in physiology · 2021Article
- Driving Oscillatory Dynamics: Neuromodulation for Recovery After Stroke.Frontiers in systems neuroscience · 2021Review
- Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue.Cardiovascular research · 2020Article
- Non-invasive red-light optogenetic control of Drosophila cardiac function.Communications biology · 2020Article
- Cardiac Optogenetics in Atrial Fibrillation: Current Challenges and Future Opportunities.BioMed research international · 2020Review
- Optogenetics: Background, Methodological Advances and Potential Applications for Cardiovascular Research and Medicine.Frontiers in bioengineering and biotechnology · 2019Review
- Principles of Optogenetic Methods and Their Application to Cardiac Experimental Systems.Frontiers in physiology · 2019Review
- Cardiac Optogenetics: 2018.JACC. Clinical electrophysiology · 2018Review
- Termination of re-entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models.The Journal of physiology · 2018Article
- Cardiac optogenetics: using light to monitor cardiac physiology.Basic research in cardiology · 2017Review
- Anion channelrhodopsins for inhibitory cardiac optogenetics.Scientific reports · 2016Article
- Ultrasound modulates ion channel currents.Scientific reports · 2016Article
- Light-based Approaches to Cardiac Arrhythmia Research: From Basic Science to Translational Applications.Clinical Medicine Insights. Cardiology · 2016Review
- Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability.Scientific reports · 2015Article
- Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations.Computers in biology and medicine · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Optogenetics is an exciting new technology in which viral gene or cell delivery is used to inscribe light sensitivity in excitable tissue to enable optical control of bioelectric behavior. Initial progress in the fledgling domain of cardiac optogenetics has included in vitro expression of various light-sensitive proteins in cell monolayers and transgenic animals to demonstrate an array of potentially useful applications, including light-based pacing, silencing of spontaneous activity, and spiral wave termination. In parallel to these developments, the cardiac modeling community has developed a versatile computational framework capable of realistically simulating optogenetics in biophysically detailed, patient-specific representations of the human heart, enabling the exploration of potential clinical applications in a predictive virtual platform. Toward the ultimate goal of assessing the feasibility and potential impact of optogenetics-based therapies in cardiovascular medicine, this review provides (1) a detailed synopsis of in vivo, in vitro, and in silico developments in the field and (2) a critical assessment of how existing clinical technology for gene/cell delivery and intra-cardiac illumination could be harnessed to achieve such lofty goals as light-based arrhythmia termination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.