ArticleNeuron2014
Configural and elemental coding of natural odor mixture components in the human brain.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Titrating the Smell of Fear: Initial Evidence for Dose-Invariant Behavioral, Physiological, and Neural Responses.Psychological science · 2021Trial
- Elements of olfactory intelligence in Drosophila.Biological cybernetics · 2026Article
- Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Semantic context-dependent neural representations of odors in the human piriform cortex revealed by 7T MRI.Human brain mapping · 2024Article
- Leveraging multi-echo EPI to enhance BOLD sensitivity in task-based olfactory fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Neural mechanisms underlying the hierarchical construction of perceived aesthetic value.Nature communications · 2023Article
- The neural substrates responsible for food odor processing: an activation likelihood estimation meta-analysis.Frontiers in neuroscience · 2023Article
- Olfactory responses ofeLife · 2022Article
- Odor mixture perception during flavor consumption in rats.Behavioral neuroscience · 2022Article
- On the state-dependent nature of odor perception.Frontiers in neuroscience · 2022Review
- The role of viscosity in flavor preference: plasticity and interactions with taste.Chemical senses · 2022Article
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- The hierarchical construction of value.Current opinion in behavioral sciences · 2021Article
- Olfactory perceptual decision-making is biased by motivational state.PLoS biology · 2021Article
- Aesthetic preference for art can be predicted from a mixture of low- and high-level visual features.Nature human behaviour · 2021Article
- Some like it, some do not: behavioral responses and central processing of olfactory-trigeminal mixture perception.Brain structure & function · 2021Article
- Comparative Study of Brain fMRI of Olfactory Stimulation in Neuromyelitis Optica Spectrum Disease and Multiple Sclerosis.Frontiers in neuroscience · 2021Article
- Fruit flies can learn non-elemental olfactory discriminations.Proceedings. Biological sciences · 2020Article
- Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states.eLife · 2020Article
- Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Most real-world odors are complex mixtures of distinct molecular components. Olfactory systems can adopt different strategies to contend with this stimulus complexity. In elemental processing, odor perception is derived from the sum of its parts; in configural processing, the parts are integrated into unique perceptual wholes. Here we used gas-chromatography/mass-spectrometry techniques to deconstruct a complex natural food smell and assess whether olfactory salience is confined to the whole odor or is also embodied in its parts. By implementing an fMRI sensory-specific satiety paradigm, we identified reward-based changes in orbitofrontal cortex (OFC) for the whole odor and for a small subset of components. Moreover, component-specific changes in OFC-amygdala connectivity correlated with perceived value. Our findings imply that the human brain has direct access to the elemental content of a natural food odor, and highlight the dynamic capacity of the olfactory system to engage both object-level and component-level mechanisms to subserve behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.