Evidence map›Paper›PMID 25453725›Full record

ArticleAnnals of epidemiology2015

Individualized diagnosis interventions can add significant effectiveness in reducing human immunodeficiency virus incidence among men who have sex with men: insights from Southern California.

Aditya Khanna, Steven M Goodreau, Dan Wohlfeiler, Eric Daar, Susan Little, Pamina M Gorbach

Open access · bronzeAbstract read
In one paragraph

Article in Annals of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Aditya KhannaDepartment of Medicine, University of Chicago, Chicago, IL. Electronic address: akhanna@medicine.bsd.uchicago.edu.
Steven M GoodreauDepartment of Anthropology, University of Washington, Seattle, WA.
Dan WohlfeilerDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA.
Eric DaarDavid Geffen School of Medicine, University of California, Los Angeles, CA.
Susan LittleDepartment of Medicine, University of California, San Diego, CA.
Pamina M GorbachFielding School of Public Health, David Geffen School of Medicine, University of California, Los Angeles, CA.
Fielding Graduate University · USUniversity of California, Los Angeles · USUniversity of California, San Diego · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transmission ProbabilityP01AI074621 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2008 to 2012
$23.1M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Southern California Primary Infection ProgramU01AI043638 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHMAN, DOUGLAS D · 1998 to 2010
$21.3M
Methods and Data CoreR24HD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI MAR, CORINNE M · 2002 to 2016
$9.3M
Scientific/Technical CoreP2CHD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI Daniel T A Eisenberg · 2017 to 2026
$6.3M
Prevention Umbrella for MSM in the AmericasR01AI083060 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI BUCHBINDER, SUSAN · 2009 to 2012
$3.7M
Efficacy of ART to Interrupt HIV Transmission NetworksR01MH100974 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2014 to 2018
$3.2M
Statistical Methods for Network EpidemiologyR01HD068395 · NICHD · UNIVERSITY OF WASHINGTON · PI MORRIS, WANDA MARTINA · 2011 to 2015
$3.0M
Social Network Dynamics, HIV, and Risk Reduction Among Younger Black MSMR01DA033875 · NIDA · NATIONAL OPINION RESEARCH CENTER · PI SCHNEIDER, JOHN · 2012 to 2016
$3.0M
TransmissionBehavior in Partnerships of Newly HIV Infected Southern CaliforniansR01DA022116 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORBACH, PAMINA MAE · 2007 to 2011
$2.7M
NCATS NIH HHS UL1 TR000124NIAID NIH HHS P01 AI 074621NIAID NIH HHS P01 AI074621NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI 083060NIAID NIH HHS R01 AI083060NIAID NIH HHS R24 AI 106039NIAID NIH HHS R24 AI106039NIAID NIH HHS U01 AI043638NICHD NIH HHS P2C HD042828NICHD NIH HHS R01 HD 068395NICHD NIH HHS R01 HD068395NICHD NIH HHS R24 HD 042828NICHD NIH HHS R24 HD042828NICHD NIH HHS T32 HD007543NIDA NIH HHS R01 DA 022116NIDA NIH HHS R01 DA022116NIDA NIH HHS R01 DA 033875NIDA NIH HHS R01 DA033875NIMH NIH HHS R01 MH100974
6 · The paper itself

Abstract

purposeIn this article, we examine the effectiveness of a variety of HIV diagnosis interventions in recently HIV-diagnosed men who have sex with men (MSM). These interventions use the preventive potential of postdiagnosis behavior change (PDBC), as measured by the reduction in the number of new infections. Empirical evidence for PDBC was presented in the behavioral substudy of the Southern California Acute Infection and Early Disease Research Program. In previous modeling work, we demonstrated the existing preventive effects of PDBC. However, a large proportion of new infections among MSM are either undiagnosed or diagnosed late, and the preventive potential of PDBC is not fully utilized.

methodsWe derive empirical, stochastic, network-based models to examine the effectiveness of several diagnosis interventions that account for PDBC among MSM over a 10-year period. These interventions involve tests with shorter detection windows, more frequent testing, and individualized testing regimens.

resultsWe find that individualized testing interventions (i.e., testing individuals every three partners or 3 months, whichever is first, or every six partners or 6 months, whichever is first) result in significantly fewer new HIV infections than the generalized interventions we consider.

conclusionsThis work highlights the potential of individualized interventions for new public health policies in HIV prevention.

Indexed as

AIDS SerodiagnosisHomosexuality, MaleCaliforniaHIV InfectionsHumansIncidenceMalePrecision MedicineRisk Reduction BehaviorRisk-TakingSexual PartnersYoung AdultDiagnosis strategiesExponential random graph models (ERGMs)Men who have sex with men (MSM)Network modelsTesting as prevention

Identifiers

PMID25453725
PMCPMC4255290
OpenAlexW2116957757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.